Multidrug-Resistant Tuberculosis in Europe, 2010-2011

被引：71

作者：

Guenther, Gunar ^{[1
,2
]}

van Leth, Frank ^{[3
]}

Alexandru, Sofia ^{[4
]}

Altet, Neus ^{[5
,6
]}

Avsar, Korkut ^{[7
]}

Bang, Didi ^{[8
,9
]}

Barbuta, Raisa ^{[10
]}

Bothamley, Graham ^{[11
]}

Ciobanu, Ana ^{[4
]}

Crudu, Valeriu ^{[4
,12
]}

Danilovits, Manfred ^{[13
]}

Dedicoat, Martin ^{[14
,15
]}

Duarte, Raquel ^{[16
,17
]}

Gualano, Gina ^{[18
]}

Kunst, Heinke ^{[15
,19
]}

de Lange, Wiel ^{[20
]}

Leimane, Vaira ^{[21
]}

Magis-Escurra, Cecile ^{[22
]}

McLaughlin, Anne-Marie ^{[23
]}

Muylle, Inge ^{[24
]}

Polcova, Veronika ^{[25
]}

Pontalli, Emanuele ^{[26
]}

Popa, Christina ^{[27
]}

Rumetshofer, Rudolf ^{[28
]}

Skrahina, Alena ^{[29
]}

Solodovnikova, Varvara ^{[29
]}

Spinu, Victor ^{[27
]}

Tiberi, Simon ^{[30
,31
]}

Viiklepp, Piret ^{[32
]}

Lange, Christoph ^{[1
,2
,33
]}

机构：

[1] Univ Namibia, Sch Med, Windhoek, Namibia

[2] Res Ctr Borstel, German Ctr Infect Res, D-23845 Borstel, Germany

[3] Univ Amsterdam, Amsterdam, Netherlands

[4] Inst Phthisiopneumol, Kishinev, Moldova

[5] Hosp Univ Vall dHebron, Barcelona, Spain

[6] Jordi Gol Univ, Barcelona, Spain

[7] Asklepios Klin Gauting, Gauting, Germany

[8] Statens Serum Inst, DK-2300 Copenhagen, Denmark

[9] Herlev Hosp, DK-2730 Herlev, Denmark

[10] Balti Municipal Hosp, Balti, Moldova

[11] Homerton Univ Hosp, London, England

[12] Natl TB Reference Lab, Kishinev, Moldova

[13] Univ Tartu, Lung Hosp, EE-50090 Tartu, Estonia

[14] Univ Warwick, Coventry CV4 7AL, W Midlands, England

[15] Heart England Fdn Trust, Birmingham, W Midlands, England

[16] Vila Nova de Gaia Espinho Med Sch, Vila Nova De Gaia, Portugal

[17] Univ Porto, P-4100 Oporto, Portugal

[18] Natl Inst Infect Dis L Spallanzani, Rome, Italy

[19] Queen Mary Univ, London, England

[20] Univ Groningen, Univ Med Ctr Groningen, NL-9713 AV Groningen, Netherlands

[21] Riga East Univ Hosp, Riga, Latvia

[22] Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands

[23] St James Hosp, Dublin 8, Ireland

[24] Univ Med Ctr St Pieter, Brussels, Belgium

[25] Thomayer Univ Hosp, Prague, Czech Republic

[26] Galliera Hosp, Genoa, Italy

[27] Marius Nasta Inst, Bucharest, Romania

[28] Otto Wagner Hosp, Vienna, Austria

[29] Republican Res & Pract Ctr Pulmonol & TB, Minsk, BELARUS

[30] Azienda Osped Valtellina & Valchiavenna E Morelli, Sondalo, Italy

[31] Barts Hlth Natl Hlth Serv Trust, London, England

[32] Natl Inst Hlth Dev, Tallinn, Estonia

[33] Karolinska Inst, Stockholm, Sweden

来源：

EMERGING INFECTIOUS DISEASES | 2015年 / 21卷 / 03期

关键词：

DRUGS;

D O I：

10.3201/eid2103.141343

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Drug-resistant Mycobacterium tuberculosis is challenging elimination of tuberculosis (TB). We evaluated risk factors for TB and levels of second-line drug resistance in M. tuberculosis in patients in Europe with multidrug-resistant (MDR) TB. A total of 380 patients with MDR TB and 376 patients with non-MDR TB were enrolled at 23 centers in 16 countries in Europe during 2010-2011. A total of 52.4% of MDR TB patients had never been treated for TB, which suggests primary transmission of MDR M. tuberculosis. At initiation of treatment for MDR TB, 59.7% of M. tuberculosis strains tested were resistant to pyrazinamide, 51.1% were resistant to >= 1 second-line drug, 26.6% were resistant to second-line injectable drugs, 17.6% were resistant to fluoroquinolones, and 6.8% were extensively drug resistant. Previous treatment for TB was the strongest risk factor for MDR TB. High levels of primary transmission and advanced resistance to second-line drugs characterize MDR TB cases in Europe.

引用

页码：409 / 416

页数：8

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