Chiral supramolecular coordination cages as high-performance inhibitors against amyloid-β aggregation

被引：15

作者：

Bao, Ling-Yu ^{[1
]}

Hao, Si-Jia ^{[1
]}

Xi, Sai-Fei ^{[1
]}

Yan, Xiaodong ^{[1
]}

Zhang, Hai-Xia ^{[1
]}

Shen, Rui ^{[1
]}

Gu, Zhi-Guo ^{[1
,2
]}

机构：

[1] Jiangnan Univ, Key Lab Synthet & Biol Colloids, Minist Educ, Sch Chem & Mat Engn, Wuxi 214122, Peoples R China

[2] Jiangnan Univ, Int Joint Res Ctr Photorespons Molecules & Mat, Sch Chem & Mat Engn, Wuxi 214122, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 63期

基金：

中国国家自然科学基金;

关键词：

ALZHEIMERS-DISEASE; THIOFLAVIN-T; PROTEIN; METAL; TOXICITY; OLIGOMERIZATION; MECHANISMS; CURCUMIN; EXCHANGE; FIBRILS;

D O I：

10.1039/c8cc04913k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Four pairs of chiral supramolecular coordination cages were facilely synthesized, and they could efficiently inhibit amyloid-beta (A beta) aggregation with a high inhibition rate of 0.64-0.86. This research provides a new perspective on the design of chiral A beta inhibitors using supramolecular metal-organic cages.

引用

收藏

页码：8725 / 8728

页数：4

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