Chiral supramolecular coordination cages as high-performance inhibitors against amyloid-β aggregation

被引：15
作者：
Bao, Ling-Yu [1 ]
Hao, Si-Jia [1 ]
Xi, Sai-Fei [1 ]
Yan, Xiaodong [1 ]
Zhang, Hai-Xia [1 ]
Shen, Rui [1 ]
Gu, Zhi-Guo [1 ,2 ]
机构：
[1] Jiangnan Univ, Key Lab Synthet & Biol Colloids, Minist Educ, Sch Chem & Mat Engn, Wuxi 214122, Peoples R China
[2] Jiangnan Univ, Int Joint Res Ctr Photorespons Molecules & Mat, Sch Chem & Mat Engn, Wuxi 214122, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 63期
基金：
中国国家自然科学基金;
关键词：
ALZHEIMERS-DISEASE; THIOFLAVIN-T; PROTEIN; METAL; TOXICITY; OLIGOMERIZATION; MECHANISMS; CURCUMIN; EXCHANGE; FIBRILS;
D O I：
10.1039/c8cc04913k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Four pairs of chiral supramolecular coordination cages were facilely synthesized, and they could efficiently inhibit amyloid-beta (A beta) aggregation with a high inhibition rate of 0.64-0.86. This research provides a new perspective on the design of chiral A beta inhibitors using supramolecular metal-organic cages.
引用
收藏
页码：8725 / 8728
页数：4
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