Visible Light-Induced Hydroxyalkylation of Heteroarenes with Aliphatic Alcohols

被引：4
|
作者：
Xu Dongping [1 ]
Huang Fei [1 ]
Tang Lin [1 ]
Zhang Xinming [1 ]
Zhang Wu [1 ]
机构：
[1] Anhui Normal Univ, Coll Chem & Mat Sci, Wuhu 241000, Anhui, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 42卷 / 05期
关键词：
alcohol; cross-dehydrogenative coupling; heteroarene; hydroxyalkylation; visible light-induction; C-H FUNCTIONALIZATION; PHOTOREDOX CATALYSIS; AMINATION REACTIONS; CARBOXYLIC-ACIDS; METAL; ETHERS; C(SP(3))-H; QUINOXALIN-2(1H)-ONES; HETEROARYLATION; AMINES;
D O I：
10.6023/cjoc202112032
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient visible light-induced direct cross-dehydrogenative coupling of heteroarenes with aliphatic alcohols in aqueous solution at ambient temperature was developed. The reaction is initiated by persulfate salts and does not require the use of stoichiometric acid for activation of the heterocycle. alpha-Hydroxyalkyl radicals transiently generated from alcohols via hydrogen atom transfer (HAT) undergo Minisci-type reactions with a range of heteroarenes. This protocol was highlighted by photocatalyst-free, green solvent, mild conditions, readily available starting materials, and wide functional group tolerance.
引用
收藏
页码：1493 / 1500
页数：8
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