Modulation of effective connectivity during emotional processing by Δ9-tetrahydrocannabinol and cannabidiol

被引:129
作者
Fusar-Poli, Paolo [1 ,2 ]
Allen, Paul [1 ]
Bhattacharyya, Sagnik [1 ]
Crippa, Jose A. [1 ,3 ,4 ]
Mechelli, Andrea [1 ]
Borgwardt, Stefan [1 ,5 ]
Martin-Santos, Rocio [1 ]
Seal, Marc L. [1 ,6 ]
O'Carrol, Colin [1 ]
Atakan, Zerrin [1 ]
Zuardi, Antonio W. [3 ,4 ]
McGuire, Philip [1 ]
机构
[1] Kings Coll London, Inst Psychiat, Div Psychol Med, Neuroimaging Sect, London, England
[2] Univ Pavia, Dept Hlth Sci, Sect Psychiat, I-27100 Pavia, Italy
[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Neurosci & Behav, BR-05508 Sao Paulo, Brazil
[4] INCT Translat Med, Ribeirao Preto, Brazil
[5] Univ Basel Hosp, Psychiat Outpatient Dept, Basel, Switzerland
[6] Univ Melbourne, Melbourne Neuropsychiat Ctr, Melbourne, Vic 3010, Australia
关键词
Anxiety; cannabis; effective connectivity; emotion; fMRI; ANTERIOR CINGULATE CORTEX; MEDIAL PREFRONTAL CORTEX; FACIAL EXPRESSIONS; NEURAL RESPONSE; DOPAMINE LEVELS; HUMAN AMYGDALA; ACTIVATION; DELTA-9-TETRAHYDROCANNABINOL; RAT; INVOLVEMENT;
D O I
10.1017/S1461145709990617
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Cannabis sativa, the most widely used illicit drug, has profound effects on levels of anxiety in animals and humans. Although recent studies have helped provide a better understanding of the neurofunctional correlates of these effects, indicating the involvement of the amygdala and cingulate cortex, their reciprocal influence is still mostly unknown. In this study dynamic causal modelling (DCM) and Bayesian model selection (BMS) were used to explore the effects of pure compounds of C. sativa [600 mg of cannabidiol (CBD) and 10 mg Delta(9)-tetrahydrocannabinol (Delta(9)-THC)] on prefrontal-subcortical effective connectivity in 15 healthy subjects who underwent a double-blind randomized, placebo-controlled fMRI paradigm while viewing faces which elicited different levels of anxiety. In the placebo condition, BMS identified a model with driving inputs entering via the anterior cingulate and forward intrinsic connectivity between the amygdala and the anterior cingulate as the best fit. CBD but not Delta(9)-THC disrupted forward connectivity between these regions during the neural response to fearful faces. This is the first study to show that the disruption of prefrontal-subocrtical connectivity by CBD may represent neurophysiological correlates of its anxiolytic properties.
引用
收藏
页码:421 / 432
页数:12
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