Past, present, and emerging roles of mitochondrial heat shock protein TRAP1 in the metabolism and regulation of cancer stem cells

被引：28
作者：
Im, Chang-Nim [1 ,2 ,3 ]
机构：
[1] Catholic Univ Korea, Dept Biochem, Coll Med, Seoul 137701, South Korea
[2] Catholic Univ Korea, Inst Aging & Metab Dis, Coll Med, Seoul 137701, South Korea
[3] Catholic Univ Korea, Coll Med, Canc Evolut Res Ctr, Seoul 137701, South Korea
来源：
CELL STRESS & CHAPERONES | 2016年 / 21卷 / 04期
基金：
新加坡国家研究基金会;
关键词：
TRAP1; Apoptosis; Fatty liver; Cancer stem cells; Warburg effect; NECROSIS-FACTOR RECEPTOR; BREAST-CARCINOMA CELLS; CHAPERONE TRAP1; ENDOPLASMIC-RETICULUM; CELLULAR SENESCENCE; GLIOBLASTOMA CELLS; PARKINSON DISEASE; OXIDATIVE STRESS; QUALITY-CONTROL; HSP90;
D O I：
10.1007/s12192-016-0687-3
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Tumor necrosis factor receptor-associated protein 1 (TRAP1), a member of the HSP90 family, controls a variety of physiological functions, including cell proliferation, differentiation, and survival. Most studies have been devoted to understanding the anti-apoptotic roles of TRAP1 in cancer and targeting it for tumor control in clinical settings. Additionally, we have identified a new role for TRAP1 in regulation of liver regeneration after partial hepatectomy in TRAP1 transgenic mice and cellular proliferation in TRAP1-overexpressing cells, via mitochondrial alterations. Moreover, recent works have indicated a role for TRAP1 in the regulation of cancer stem cells (CSCs) as well as a metabolic switch between mitochondrial respiration and aerobic glycolysis called as "Warburg effect." This review discusses the implications of TRAP1 action for both metabolism and the regulation of CSCs.
引用
收藏
页码：553 / 562
页数：10
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