Gonadotropin inhibitory hormone function in mammals

被引：63

作者：

Smith, Jeremy T. ^{[1
]}

Clarke, Iain J. ^{[1
]}

机构：

[1] Monash Univ, Dept Physiol, Clayton, Vic 3800, Australia

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2010年 / 21卷 / 04期

基金：

英国医学研究理事会;

关键词：

RFAMIDE-RELATED PEPTIDE; LUTEINIZING-HORMONE; LH-SECRETION; HYPOPHYSIOTROPIC ROLE; FEEDING-BEHAVIOR; NEUROPEPTIDE FF; ENERGY-BALANCE; CDNA CLONING; MALE RATS; EXPRESSION;

D O I：

10.1016/j.tem.2009.11.010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Reproductive function depends on the stimulatory action of gonadotropin-releasing hormone (GnRH), secreted by the brain. Original work in birds identified and isolated a peptide that inhibits gonadotropin release, named gonadotropin inhibitory hormone (GnIH). There is no evidence for a similar factor operant in mammals. This mammalian orthologue of GnIH has been named RFamide-related peptide (RFRP), and negatively regulates GnRH function and gonadotropin secretion. In particular, mammalian GnIH inhibits the function of GnRH cells and acts at the level of gonad. tropes. It appears to play a major role in seasonal regulation of reproduction and also to be involved in regulation of stress and food intake.

引用

页码：255 / 260

页数：6

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