Ursolic acid a promising candidate in the therapeutics of breast cancer: Current status and future implications

被引：91

作者：

Iqbal, Javed ^{[1
]}

Abbasi, Banzeer Ahsan ^{[1
]}

Ahmad, Riaz ^{[6
]}

Mahmood, Tariq ^{[1
]}

Kanwal, Sobia ^{[2
]}

Ali, Barkat ^{[1
]}

Khalil, Ali Talha ^{[3
,4
,5
]}

Shah, Sayed Afzal ^{[1
]}

Alam, Muhammad Maqsood ^{[1
]}

Badshah, Hussain ^{[1
]}

机构：

[1] Quaid I Azam Univ Islamabad, Dept Plant Sci, Islamabad 45320, Pakistan

[2] Univ Gujrat, Dept Zool, Sub Campus Rawalpindi, Rawalpindi, Pakistan

[3] Univ South Africa, Coll Grad Studies, UNESCO UNISA Africa Chair Nanosci & Nanotechnol, ZA-0002 Pretoria, South Africa

[4] Natl Res Fdn Somerset West, iThemba LABS, Nanosci African Network NANOAFNET, ZA-7129 Western Cape, South Africa

[5] Qarshi Univ, Dept Eastern Med & Surg, Lahore 56000, Pakistan

[6] Shaanxi Normal Univ, Coll Life Sci, Xian 710119, Shaanxi, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2018年 / 108卷

关键词：

Breast cancer; Ursolic acid; Phytochemicals; In vitro; In vivo; APPLE PEELS; APOPTOSIS; CELLS; PHARMACOKINETICS; PHOSPHORYLATION; PROLIFERATION; TRITERPENES; VOLUNTEERS; AUTOPHAGY; KINASE;

D O I：

10.1016/j.biopha.2018.09.096

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Breast cancer [BC] is the deadliest neoplasm in women globally and the second leading cause of cancer associated deaths. Current treatment methods include chemotherapy, hormonal therapy, radiation therapy and surgery. However, BC has shown resistance to these therapies and are often associated with side effects, multidrug resistance, recurrence are the major issues in BC treatment. Currently, dietary phytocompounds have emerged as beneficial agents for the prevention and treatment of cancer because of their safe and cost effective nature. Ursolic acid [UA] is widely spread in fruits and vegetables having the ability to inhibit BC proliferation, angiogenesis and metastasis, arrest cell cycle, induced apoptosis, scavenge free radicals and regulate several anti-apoptotic and pro-apoptotic proteins. UA has also shown potential anticancer, anti-inflammatory and anti-oxidant activities in several human BC cells. This review paper encompasses the role of UA against BC and their mechanism of action in vitro and in vivo studies.

引用

页码：752 / 756

页数：5