Does prostate cancer aggressiveness change with increasing age?

In United States and many European countries, prostate cancer is the most common non-dermatological malignancy in men (1). Old age is a well-established risk factor for prostate cancer. More than half of incident prostate cancer cases and more than 90% of deaths from prostate cancer occur in men aged 65 years or more (2). As the life expectancy continues to rise in most developed countries as a result of decreasing old-age mortality (3), men will be increasingly likely to live long enough to develop symptomatic or even fatal prostate cancer. Prostate cancer in the elderly people therefore represents an increasingly important health problem. The relationship between age and prostate cancer biology is, however, subject to controversies (4,5).