Prognostic significance of c-erbB-2 and c-myc expression in relation with tumor size, differentiation and status in breast cancer

被引：0

作者：

Kokkofitis, A ^{[1
]}

Leivaditou, A ^{[1
]}

Antoniou, I ^{[1
]}

Varatsos, A ^{[1
]}

Tallas, V ^{[1
]}

Theophilogiannakos, K ^{[1
]}

Miligos, N ^{[1
]}

Manuras, A ^{[1
]}

Golematis, V ^{[1
]}

机构：

[1] Univ Athens, Ippokrat Gen Hosp, Surg Dept A, Athens, Greece

来源：

10TH INTERNATIONAL CONGRESS ON SENOLOGY - BREAST DISEASES OF THE SENOLOGIC INTERNATIONAL SOCIETY | 1998年

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D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Various studies have reported a relationship between c-erbB-2 and c-myc expression and established prognostic indicators, as well as the clinical course in breast cancer patients. In this report ninety paraffin-embedded breast cancer tissue samples were analysed for detecting the expression of the c-erbB-2 and c-myc oncogene by immunoperoxidase-avidin-biotin technique. c-erbB-2 cell membrane staining was observed in 32,2% of the cases and was found to be related to tumor size 37,7% histopathologic types and grade 60% and node-positive patients 37,8%. c-myc cell membrane staining was observed in 93,3% and there was no association with tumor size, tumor type, grade and nodal status. There was no correlation between c-myc amplification and unfavourable clinical outcome. In this study, immunohistochemical expression of c-erbB-2 proto-oncogene product was correlated to tumor characteristics associated with unfavourable clinical outcome,i.e. large tumor size, poor differentiation of the tumor cells and nodal status.

引用

页码：681 / 684

页数：4