Synthesis of Enantioenriched Vicinal Tertiary and Quaternary Carbon Stereogenic Centers within an Acyclic Chain

被引：112

作者：

Pierrot, David ^{[1
]}

Marek, Ilan ^{[1
]}

机构：

[1] Technion Israel Inst Technol, Schulich Fac Chem, Mallat Family Lab Organ Chem, IL-3200009 Haifa, Israel

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2020年 / 59卷 / 01期

基金：

欧洲研究理事会;

关键词：

diastereodivergence; quaternary stereogenic centers; stereogenic centers; tertiary stereogenic centers; vicinal positions; ASYMMETRIC ALLYLIC ALKYLATION; C-C BONDS; CATALYTIC ENANTIOSELECTIVE CONSTRUCTION; REMOTE FUNCTIONALIZATION; ALPHA; ALPHA-DISUBSTITUTED ALDEHYDES; CLAISEN REARRANGEMENT; CONTIGUOUS QUATERNARY; CONJUGATE ADDITIONS; ADJACENT QUATERNARY; MICHAEL ADDITION;

D O I：

10.1002/anie.201903188

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Overcoming the inherent difficulty to prepare quaternary carbon stereogenic centers, the diastereo- and enantioselective preparation of acyclic carbon backbones possessing vicinal quaternary and tertiary stereogenic centers (i.e. in a 1,2-relationship) causes distorted geometries and represents a very acute problem in organic synthesis. Several approaches are discussed in this minireview underlining the challenges illustrated by the rather limited number of approaches available to practitioners.

引用

页码：36 / 49

页数：14

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