One-Pot Strategies for the Synthesis of the Tetrasaccharide Linkage Region of Proteoglycans

被引：34
|
作者：
Huang, Teng-Yi [1 ,2 ]
Zulueta, Medel Manuel L. [1 ]
Hung, Shang-Cheng [1 ,3 ]
机构：
[1] Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan
[2] Natl Tsing Hua Univ, Dept Chem, Hsinchu 300, Taiwan
[3] Natl Chiao Tung Univ, Dept Appl Chem, Hsinchu 300, Taiwan
来源：
ORGANIC LETTERS | 2011年 / 13卷 / 06期
关键词：
BIOSYNTHESIS; OLIGOSACCHARIDE; DISACCHARIDE; PROTECTION; GLYCOSAMINOGLYCANS; TRISACCHARIDE; DERIVATIVES; SULFOFORMS; GALACTOSE; EFFICIENT;
D O I：
10.1021/ol200192d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A linker-attached tetrasaccharide corresponding to the linkage region of proteoglycans was synthesized via one-pot procedures from the silylated monosaccharide derivatives. Regioselective one-pot protection protocols were applied in generating the requisite monosaccharide building blocks whereas stereoselective one-pot glycosylation approaches were utilized to assemble the tetrasaccharide skeleton.
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页码：1506 / 1509
页数：4
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