One-Pot Strategies for the Synthesis of the Tetrasaccharide Linkage Region of Proteoglycans

被引：34

作者：

Huang, Teng-Yi ^{[1
,2
]}

Zulueta, Medel Manuel L. ^{[1
]}

Hung, Shang-Cheng ^{[1
,3
]}

机构：

[1] Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan

[2] Natl Tsing Hua Univ, Dept Chem, Hsinchu 300, Taiwan

[3] Natl Chiao Tung Univ, Dept Appl Chem, Hsinchu 300, Taiwan

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 06期

关键词：

BIOSYNTHESIS; OLIGOSACCHARIDE; DISACCHARIDE; PROTECTION; GLYCOSAMINOGLYCANS; TRISACCHARIDE; DERIVATIVES; SULFOFORMS; GALACTOSE; EFFICIENT;

D O I：

10.1021/ol200192d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A linker-attached tetrasaccharide corresponding to the linkage region of proteoglycans was synthesized via one-pot procedures from the silylated monosaccharide derivatives. Regioselective one-pot protection protocols were applied in generating the requisite monosaccharide building blocks whereas stereoselective one-pot glycosylation approaches were utilized to assemble the tetrasaccharide skeleton.

引用

页码：1506 / 1509

页数：4

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