Simultaneous 18F-fluciclovine Positron Emission Tomography and Magnetic Resonance Spectroscopic Imaging of Prostate Cancer

被引：4
作者：
Esmaeili, Morteza [1 ,6 ]
Tayari, Nassim [2 ]
Scheenen, Tom [2 ]
Elschot, Mattijs [1 ]
Sandsmark, Elise [1 ]
Bertilsson, Helena [3 ,4 ]
Heerschap, Arend [2 ]
Selnaes, Kirsten M. [1 ,5 ]
Bathen, Tone F. [1 ]
机构：
[1] Norwegian Univ Sci & Technol, Deparment Circulat & Med Imaging, Fac Med & Hlth Sci, Trondheim, Norway
[2] Radboud Univ Nijmegen, Dept Radiol & Nucl Med, Med Ctr, Nijmegen, Netherlands
[3] Trondheim Reg & Univ Hosp, Dept Surg, St Olavs Hosp, Trondheim, Norway
[4] Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Fac Med & Hlth Sci, Trondheim, Norway
[5] Trondheim Reg & Univ Hosp, Dept Radiol & Nucl Med, St Olavs Hosp, Trondheim, Norway
[6] Akershus Univ Hosp, Dept Radiol, Oslo, Norway
来源：
FRONTIERS IN ONCOLOGY | 2018年 / 8卷
关键词：
positron emission tomography; magnetic resonance spectroscopy; benign prostatic hyperplasia; chemical shift imaging; citrate; prostate cancer; IN-VIVO; ANTI-1-AMINO-3-F-18-FLUOROCYCLOBUTANE-1-CARBOXYLIC ACID; RADICAL PROSTATECTOMY; RADIATION-DOSIMETRY; PET/CT; PET/MRI; RISK; BIODISTRIBUTION; RECURRENCE; DIAGNOSIS;
D O I：
10.3389/fonc.2018.00516
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Purpose: To investigate the associations of metabolite levels derived from magnetic resonance spectroscopic imaging (MRSI) and F-18-fluciclovine positron emission tomography (PET) with prostate tissue characteristics. Methods: In a cohort of 19 high-risk prostate cancer patients that underwent simultaneous PET/MRI, we evaluated the diagnostic performance of MRSI and PET for discrimination of aggressive cancer lesions from healthy tissue and benign lesions. Data analysis comprised calculations of correlations of mean standardized uptake values (SUVmean), maximum SUV (SUVmax), and the MRSI-derived ratio of (total choline + spermine + creatine) to citrate (CSC/C). Whole-mount histopathology was used as gold standard. Results: The results showed a moderate significant correlation between both SUVmean and SUVmax with CSC/C ratio. Conclusions: We demonstrated that the simultaneous acquisition of F-18-fluciclovine PET and MRSI with an integrated PET/MRI system is feasible and a combination of these imaging modalities has potential to improve the diagnostic sensitivity and specificity of prostate cancer lesions.
引用
收藏
页数：7
相关论文
共 40 条
[11]   EAU Guidelines on Prostate Cancer. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent-Update 2013 [J].
Heidenreich, Axel ;
Bastian, Patrick J. ;
Bellmunt, Joaquim ;
Bolla, Michel ;
Joniau, Steven ;
van der Kwast, Theodor ;
Mason, Malcolm ;
Matveev, Vsevolod ;
Wiegel, Thomas ;
Zattoni, F. ;
Mottet, Nicolas .
EUROPEAN UROLOGY, 2014, 65 (01) :124-137
[12]   Prostate Cancer: Multiparametric MR Imaging for Detection, Localization, and Staging [J].
Hoeks, Caroline M. A. ;
Barentsz, Jelle O. ;
Hambrock, Thomas ;
Yakar, Derya ;
Somford, Diederik M. ;
Heijmink, Stijn W. T. P. J. ;
Scheenen, Tom W. J. ;
Vos, Pieter C. ;
Huisman, Henkjan ;
van Oort, Inge M. ;
Witjes, J. Alfred ;
Heerschap, Arend ;
Fuetterer, Jurgen J. .
RADIOLOGY, 2011, 261 (01) :46-66
[13]  
Jemal A, 2011, CA-CANCER J CLIN, V61, P134, DOI [10.3322/caac.21492, 10.3322/caac.20115, 10.3322/caac.20107]
[14]   Citrate concentrations in human seminal fluid and expressed prostatic fluid determined via 1H nuclear magnetic resonance spectroscopy outperform prostate specific antigen in prostate cancer detection [J].
Kline, Eric E. ;
Treat, Eric G. ;
Averna, Tiffany A. ;
Davis, Michael S. ;
Smith, Anthony Y. ;
Sillerud, Laurel O. .
JOURNAL OF UROLOGY, 2006, 176 (05) :2274-2279
[15]   Contribution of Histopathologic Tissue Composition to Quantitative MR Spectroscopy and Diffusion-weighted Imaging of the Prostate [J].
Kobus, Thiele ;
van der Laak, Jeroen A. W. M. ;
Maas, Marnix C. ;
Hambrock, Thomas ;
Bruggink, Caroline C. ;
Hulsbergen-van de Kaa, Christina A. ;
Scheenen, Tom W. J. ;
Heerschap, Arend .
RADIOLOGY, 2016, 278 (03) :801-811
[16]   Metabolite Ratios in 1H MR Spectroscopic Imaging of the Prostate [J].
Kobus, Thiele ;
Wright, Alan J. ;
Weiland, Elisabeth ;
Heerschap, Arend ;
Scheenen, Tom W. J. .
MAGNETIC RESONANCE IN MEDICINE, 2015, 73 (01) :1-12
[17]   Mapping of prostate cancer by 1H MRSI [J].
Kobus, Thiele ;
Wright, Alan J. ;
Scheenen, Tom W. J. ;
Heerschap, Arend .
NMR IN BIOMEDICINE, 2014, 27 (01) :39-52
[18]   Magnetic Resonance Spectroscopy of Prostate Cancer [J].
Kurhanewicz, John ;
Vigneron, Daniel B. .
EMAGRES, 2016, 5 (01) :923-943
[19]   Leucine Modulates Mitochondrial Biogenesis and SIRT1-AMPK Signaling in C2C12 Myotubes [J].
Liang, Chunzi ;
Curry, Benjamin J. ;
Brown, Patricia L. ;
Zemel, Michael B. .
JOURNAL OF NUTRITION AND METABOLISM, 2014, 2014
[20]   The clinical safety, biodistribution and internal radiation dosimetry of [18F]fluciclovine in healthy adult volunteers [J].
McParland, Brian J. ;
Wall, Anders ;
Johansson, Silvia ;
Sorensen, Jens .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2013, 40 (08) :1256-1264
1234