The Significance of Single-Cell Biomedicine in Stem Cells

被引：5
作者：
Zhuge, Weishan [1 ]
Yan, Furong [2 ]
Zhu, Zhitu [3 ]
Wang, Xiangdong [1 ]
机构：
[1] Fudan Univ, Shanghai Med Sch, Zhongshan Hosp, Inst Clin Sci, Shanghai, Peoples R China
[2] Fujian Med Univ, Hosp 2, Dept Resp Pulm & Crit Care Med, Quanzhou, Fujian, Peoples R China
[3] Jinzhou Med Univ, Hosp 1, Jinzhou, Liaoning, Peoples R China
来源：
SINGLE CELL BIOMEDICINE | 2018年 / 1068卷
关键词：
Single-cell technology; Stein cell; Tumor; Heterogeneity; Microfluidics; LUNG-CANCER; REVEALS; EXPRESSION; HETEROGENEITY; BIOMARKERS; PHENOTYPES; PROFILES; NECROSIS;
D O I：
10.1007/978-981-13-0502-3_16
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Clinical application of stem cells (SCs) progresses significantly in the treatment of a large number of diseases, e.g. leukemia, respiratory diseases, kidney disease, cerebral palsy, autism, or autoimmune diseases. Of those, the population, biological phenotypes, and functions of individual SCs are mainly concerned, due to the lack of cell separation and purification processes. The single-cell technology, including microfluidic technology and single cell genome amplification technology, is widely used to study SCs and gains some recognitions. The present review will address the importance of single-cell technologies in the recognition and heterogeneity of SCs and highlight the significance of current single cell approaches in the understanding of SC phenotypes. We also discuss the values of single-cell studies to overcome the bottleneck in explore of biological mechanisms and reveal the therapeutic potentials of SCs in diseases, especially tumor-related diseases, as new diagnostic and therapeutic strategies
引用
收藏
页码：187 / 195
页数：9
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