Mammographic density and its interaction with other breast cancer risk factors in an Asian population

被引：58
作者：
Wong, C. S. [2 ]
Lim, G. H. [3 ]
Gao, F. [4 ,5 ]
Jakes, R. W. [6 ]
Offman, J. [1 ]
Chia, K. S. [7 ]
Duffy, S. W. [1 ]
机构：
[1] Univ London, Barts & London Sch Med & Dent, Wolfson Inst Prevent Med, Canc Prevent Trials Unit,Canc Res UK Ctr Epidemio, London EC1M 6BQ, England
[2] Natl Univ Singapore, Ctr Mol Epidemiol, Singapore 117597, Singapore
[3] Natl Univ Singapore Hosp, Natl Univ Hlth Syst, Invest Med Unit, Singapore 119074, Singapore
[4] Natl Canc Ctr, Div Clin Trials & Epidemiol Sci, Singapore 169610, Singapore
[5] Duke NUS Grad Med Sch, Singapore 169857, Singapore
[6] GlaxoSmithKline Inc, WorldWide Epidemiol, Singapore 189720, Singapore
[7] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Epidemiol & Publ Hlth, Singapore 117597, Singapore
来源：
BRITISH JOURNAL OF CANCER | 2011年 / 104卷 / 05期
基金：
英国医学研究理事会;
关键词：
Asian population; body mass index; breast cancer; breast density; mammography; PARENCHYMAL PATTERNS; WOMEN; DETERMINANTS; PREVALENCE;
D O I：
10.1038/sj.bjc.6606085
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
BACKGROUND: Joint effects of mammographic density and other risk factors on breast cancer risk remain unclear. METHODS: From The Singapore Breast Screening Project, we selected 491 cases and 982 controls. Mammographic density was measured quantitatively. Data analysis was by conditional logistic regression. RESULTS: Density was a significant risk factor, adjusting for other factors. Density of 76-100% had an odds ratio of 5.54 (95% CI 2.38-12.90) compared with 0-10%. Density had significant interactions with body mass index and oral contraceptive use (P = 0.02). CONCLUSIONS: Percent density increases breast cancer risk in addition to effects of other risk factors, and modifies the effects of BMI and OCs. British Journal of Cancer (2011) 104, 871-874. doi:10.1038/sj.bjc.6606085 www.bjcancer.com Published online 18 January 2011 (C) 2011 Cancer Research UK
引用
收藏
页码：871 / 874
页数：4
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