Vascular Bmp-Msx2-Wnt signaling and oxidative stress in arterial calcification

被引:117
|
作者
Shao, Jian-Su [1 ]
Al Aly, Ziyad [1 ]
Lai, Chung-Fang [1 ]
Cai, Su-Li Cheng Jun [1 ]
Huang, Emily [1 ]
Behrmann, Abe [1 ]
Towler, Dwight A. [1 ]
机构
[1] Washington Univ, Sch Med, Dept Med, Cardiovasc Res Ctr,Div Bone & Min Dis, St Louis, MO 63110 USA
来源
SKELETAL BIOLOGY AND MEDICINE, PT B: DISEASE MECHANISMS AND THERAPEUTIC CHALLENGES | 2007年 / 1117卷
关键词
diabetes; aorta; peripheral vascular disease; medial artery calcification; vascular calcification; Wnt signaling; oxidative stress; inflammation;
D O I
10.1196/annals.1402.075
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Studies of fracture repair have revealed that paracrine endothelial-mesenchymal interactions direct bone formation that restores osseous integrity. Angiogenic growth factors and specific members of the bone morphogenetic protein (BMP) family mediate these interactions. Recently, these same signals have been shown to be critical in the vascular pathobiology of hypertension, diabetes, and atherosclerosis. In the arterial vasculature, mechanical and inflammatory redox signals, characteristic of hypertension and diabetes have emerged as a secretagogues for BMP production-with downstream activation of endothelial NADPH oxidases (Nox). Preliminary data now indicate that the paracrine signals provided by BMP and reactive oxygen species augment aortic myofibroblast Msx2-Wnt signaling and matrix turnover. The net mural response to these stimuli promotes osteogenic differentiation of calcifying vascular cells, moreover, oxidation of vascular LDL cholesterol generates oxysterols that trigger Runx2 activity via hedgehog pathways. Thus, BMP, Wnt, and hedgehog gene expression programs-osteogenic pathways highly familiar to the bone biologist-are elaborated in the arterial vasculature via redox-regulated mechanisms. In the brief review, we recount mounting evidence that points to oxidative stress as a major contributor to the pathobiology of diabetic arterial calcification.
引用
收藏
页码:40 / 50
页数:11
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