Retinal dysfunctions in schizophrenia

被引:75
作者
Balogh, Zita [1 ]
Benedek, Gyroergy [2 ]
Keri, Szabolcs [1 ]
机构
[1] Semmelweis Univ, Dept Psychiat & Psychotherapy, H-1083 Budapest, Hungary
[2] Univ Szeged, Dept Physiol, Szeged, Hungary
关键词
electroretinography; retina; schizophrenia; vision;
D O I
10.1016/j.pnpbp.2007.08.024
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The purpose of this study was to investigate the earliest stages of visual information processing using electroretinography (ERG) in patients with schizophrenia and bipolar disorder and to compare these values with those of healthy control volunteers. In the acute stage of the illness, patients with schizophrenia exhibited decreased a-wave amplitude (a measure of photoreceptor function) as compared with healthy controls. In patients with bipolar disorder, ERG measures were intact. At the baseline assessment, there was a significant negative relationship between a-wave amplitude and positive symptoms. After an 8-week follow-up period, clinical symptoms showed significant improvement and the amplitude of the a-wave significantly increased in patients with schizophrenia. At the follow-up assessment, there was no significant difference between patients with schizophrenia and controls. These results indicate that retinal dysfunctions are specific for schizophrenia, as compared with bipolar disorder, and are confined to the acute stage of the illness. (c) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码:297 / 300
页数:4
相关论文
共 25 条
  • [1] *AM PSYCH ASS, 1994, DSM IV DIAGN STAT MA
  • [2] The magnocellular visual system and schizophrenia: what can the color red tell us?
    Bedwell, JS
    Brown, JM
    Miller, LS
    [J]. SCHIZOPHRENIA RESEARCH, 2003, 63 (03) : 273 - 284
  • [3] Early-stage visual processing deficits in schizophrenia
    Butler, PD
    Javitt, DC
    [J]. CURRENT OPINION IN PSYCHIATRY, 2005, 18 (02) : 151 - 157
  • [4] Effects of typical, atypical, and no antipsychotic drugs on visual contrast detection in schizophrenia
    Chen, Y
    Levy, DL
    Sheremata, S
    Nakayama, K
    Matthysse, S
    Holzman, PS
    [J]. AMERICAN JOURNAL OF PSYCHIATRY, 2003, 160 (10) : 1795 - 1801
  • [5] Bipolar and schizophrenic patients differ in patterns of visual motion discrimination
    Chen, Yue
    Levy, Deborah L.
    Sheremata, Summer
    Holzman, Philip S.
    [J]. SCHIZOPHRENIA RESEARCH, 2006, 88 (1-3) : 208 - 216
  • [6] Membrane phospholipid composition, alterations in neurotransmitter systems and schizophrenia
    du Bois, TM
    Deng, C
    Huang, XF
    [J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2005, 29 (06) : 878 - 888
  • [7] Contribution of cone photoreceptors and post-receptoral mechanisms to the human photopic electroretinogram
    Friedburg, C
    Allen, CP
    Mason, PJ
    Lamb, TD
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 2004, 556 (03): : 819 - 834
  • [8] ABNORMAL ELECTRORETINOGRAPHY IN SCHIZOPHRENIC-PATIENTS WITH A HISTORY OF SUN GAZING
    GERBALDO, H
    THAKER, G
    TITTEL, PG
    LAYNEGEDGE, J
    MORAN, M
    DEMISCH, L
    [J]. NEUROPSYCHOBIOLOGY, 1992, 25 (02) : 99 - 101
  • [9] Forward and backward visual masking in unaffected siblings of schizophrenic patients
    Green, MF
    Nuechterlein, KH
    Breitmeyer, B
    Mintz, J
    [J]. BIOLOGICAL PSYCHIATRY, 2006, 59 (05) : 446 - 451
  • [10] THE EFFECTS OF DOPAMINE BLOCKADE ON THE HUMAN FLASH ELECTRORETINOGRAM
    HOLOPIGIAN, K
    CLEWNER, L
    SEIPLE, W
    KUPERSMITH, MJ
    [J]. DOCUMENTA OPHTHALMOLOGICA, 1994, 86 (01) : 1 - 10