Acquired hemophagocytic lymphohistiocytosis associated with multiple myeloma

被引:17
作者
Machaczka, Maciej [1 ,3 ]
Vaktnas, Johan [3 ]
Klimkowska, Monika [2 ]
Nahi, Hareth [1 ]
Hagglund, Hans [1 ]
机构
[1] Karolinska Univ, Huddinge Hosp, Hematol Ctr Karolinska, S-14186 Stockholm, Sweden
[2] Karolinska Univ, Huddinge Hosp, Dept Pathol, S-14186 Stockholm, Sweden
[3] Varberg Hosp, Dept Med, Hematol Sect, Varberg, Sweden
关键词
Hemophagocytosis; Hemophagocytic lymphohistiocytosis; Hemophagocytic syndrome; Multiple myeloma; Epilepsy; Anticonvulsants; CLINICAL-FEATURES; CHILDREN;
D O I
10.1007/s12032-010-9484-5
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Acquired or secondary hemophagocytic lymphohistiocytosis (sHLH) is a life-threatening hyperinflammation syndrome caused mostly by various infectious agents, autoimmune disorders or malignancy. So far, only anecdotal cases of sHLH associated with multiple myeloma have been published. We provide a review of all these reports and include a previously not published case of myeloma-associated sHLH in a 59-year-old male with complex partial epilepsy. Due to aggressive course of sHLH, increased awareness is indicated in all patients with malignancies which develop unremitting fever, cytopenia and splenomegaly. Early diagnosis and immediate introduction of adequate therapy is crucial for the outcome of HLH.
引用
收藏
页码:539 / 543
页数:5
相关论文
共 50 条
  • [41] Pulmonary Involvement in Patients With Hemophagocytic Lymphohistiocytosis
    Seguin, Amelie
    Galicier, Lionel
    Boutboul, David
    Lemiale, Virginie
    Azoulay, Elie
    CHEST, 2016, 149 (05) : 1294 - 1301
  • [42] A systematic review of malignancy-associated hemophagocytic lymphohistiocytosis that needs more attentions
    Wang, Hongluan
    Xiong, Lixia
    Tang, Weiping
    Zhou, Ying
    Li, Fei
    ONCOTARGET, 2017, 8 (35) : 59977 - 59985
  • [43] HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS IN CHILDREN WITH VISCERAL LEISHMANIASIS
    Blazquez-Gamero, Daniel
    Dominguez-Pinilla, Nerea
    Chicharro, Carmen
    Negreira, Sagrario
    Galan, Pilar
    Perez-Gorricho, Beatriz
    Calvo, Cristina
    Prieto, Luis
    De la Parte, Maria
    Otheo, Enrique
    Luis Vivanco, Jose
    Ruiz-Contreras, Jesus
    PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2015, 34 (06) : 667 - 669
  • [44] Hemophagocytic lymphohistiocytosis: updates and evolving concepts
    Risma, Kimberly
    Jordan, Michael B.
    CURRENT OPINION IN PEDIATRICS, 2012, 24 (01) : 9 - 15
  • [45] Hemi-meningitis with hemophagocytic lymphohistiocytosis
    Kocak, Ozan
    Yarar, Coskun
    Yimenicioglu, Sevgi
    Ekici, Arzu
    Bor, Ozcan
    ANNALS OF INDIAN ACADEMY OF NEUROLOGY, 2016, 19 (03) : 388 - 391
  • [46] Hemophagocytic lymphohistiocytosis is associated with Bartonella henselae infection in a patient with multiple susceptibility genes
    Tianjun Yang
    Qing Mei
    Lei Zhang
    Zhendong Chen
    Chunyan Zhu
    Xiaowei Fang
    Shike Geng
    Aijun Pan
    Annals of Clinical Microbiology and Antimicrobials, 19
  • [47] Familial Hemophagocytic Lymphohistiocytosis
    Degar, Barbara
    HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 2015, 29 (05) : 903 - +
  • [48] Hematopoietic Stem Cell Transplantation for Familial Hemophagocytic Lymphohistiocytosis and Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis in Japan
    Ohga, Shouichi
    Kudo, Kazuko
    Ishii, Eiichi
    Honjo, Satoshi
    Morimoto, Akira
    Osugi, Yuko
    Sawada, Akihisa
    Inoue, Masami
    Tabuchi, Ken
    Suzuki, Nobuhiro
    Ishida, Yasushi
    Imashuku, Shinsaku
    Kato, Shunichi
    Hara, Toshiro
    PEDIATRIC BLOOD & CANCER, 2010, 54 (02) : 299 - 306
  • [49] Recombinant human soluble thrombomodulin is active against hemophagocytic lymphohistiocytosis associated with acquired immunodeficiency syndrome
    SungGi Chi
    Takayuki Ikezoe
    Asako Takeuchi
    Masato Takaoka
    Akihito Yokoyama
    International Journal of Hematology, 2013, 98 : 615 - 619
  • [50] Treatment of hemophagocytic lymphohistiocytosis
    Wang, Yini
    Wang, Zhao
    CURRENT OPINION IN HEMATOLOGY, 2017, 24 (01) : 54 - 58