Sulfur-Catalyzed Oxidative Condensation of Aryl Alkyl Ketones with o-Phenylenediamines: Access to Quinoxalines

被引：16

作者：

Nguyen, Le Anh ^{[2
,3
]}

Nguyen, Thi Thu Tram ^{[4
]}

Ngo, Quoc Anh ^{[2
,3
]}

Nguyen, Thanh Binh ^{[1
]}

机构：

[1] Univ Paris Sud, Univ Paris Saclay, CNRS UPR 2301, Inst Chim Subst Naturelles, 1 Ave Terrasse, F-91198 Gif Sur Yvette, France

[2] Vietnam Acad Sci & Technol, Inst Chem, 18 Hoang Quoc Viet, Hanoi, Vietnam

[3] Vietnam Acad Sci & Technol, Grad Univ Sci & Technol, 18 Hoang Quoc Viet, Hanoi, Vietnam

[4] Can Tho Univ Med & Pharm, Fac Sci, Dept Chem, Can Tho, Vietnam

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2022年 / 364卷 / 16期

关键词：

sulfur catalysis; quinoxaline; DMSO; ELEMENTAL SULFUR; DERIVATIVES; THIOAMIDES; PHENAZINES; DESIGN; ALPHA; UNIT;

D O I：

10.1002/adsc.202200527

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

While elemental sulfur has been largely used as oxidant or sulfurating agent, its role as a catalyst has not been developed. We report here its catalytic activity in the oxidative condensation of o-phenylenediamines with acetophenones in DMSO to provide quinoxalines. The method was also extended to alpha-tetralones, propiophenones (R = Me) as well as higher homologues (R = Et, n-Pr) in place of acetophenones, leading to a wide range of naphthoquinoxalines and 3-substituted 2-arylquinoxalines.

引用

页码：2748 / 2752

页数：5

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