Clinical tumor diameter and prognosis of patients with FIGO stage IB1 cervical cancer (JCOG0806-A)

被引：81

作者：

Kato, Tomoyasu ^{[1
]}

Takashima, Atsuo ^{[2
]}

Kasamatsu, Takahiro ^{[1
]}

Nakamura, Kenichi ^{[2
]}

Mizusawa, Junki ^{[2
]}

Nakanishi, Toru ^{[3
]}

Takeshima, Nobuhiro ^{[4
]}

Kamiura, Shoji ^{[5
]}

Onda, Takashi ^{[6
]}

Sumi, Toshiyuki ^{[7
]}

Takano, Masashi ^{[8
]}

Nakai, Hidekatsu ^{[9
]}

Saito, Toshiaki ^{[10
]}

Fujiwara, Kiyoshi ^{[11
]}

Yokoyama, Masatoshi ^{[12
]}

Itamochi, Hiroaki ^{[13
]}

Takehara, Kazuhiro ^{[14
]}

Yokota, Harushige ^{[15
]}

Mizunoe, Tomoya ^{[16
]}

Takeda, Satoru ^{[17
]}

Sonoda, Kenzo ^{[18
]}

Shiozawa, Tanri ^{[19
]}

Kawabata, Takayo ^{[20
]}

Honma, Shigeru ^{[21
]}

Fukuda, Haruhiko ^{[2
]}

Yaegashi, Nobuo ^{[22
]}

Yoshikawa, Hiroyuki ^{[23
]}

Konishi, Ikuo ^{[24
]}

Kamura, Toshiharu ^{[25
]}

机构：

[1] Natl Canc Ctr, Dept Gynecol Oncol, Tokyo 1040045, Japan

[2] Natl Canc Ctr, Multiinst Clin Trial Support Ctr, Japan Clin Oncol Grp, Ctr Data, Tokyo, Japan

[3] Aichi Canc Ctr, Dept Gynecol Oncol, Nagoya, Aichi, Japan

[4] Canc Inst Hosp, Dept Gynecol, Tokyo, Japan

[5] Osaka Med Ctr Canc & Cardiovasc Dis, Dept Gynecol, Osaka, Japan

[6] Kitasato Univ, Dept Obstet & Gynecol, Minato, Tokyo, Japan

[7] Osaka City Univ, Grad Sch Med, Dept Obstet & Gynecol, Osaka, Japan

[8] Natl Def Med Coll, Dept Obstet & Gynecol, Tokorozawa, Saitama, Japan

[9] Kinki Univ, Dept Gynecol, Higashiosaka, Osaka 577, Japan

[10] Kyushu Natl Canc Ctr, Gynecol Serv, Yokohama, Kanagawa, Japan

[11] Hyogo Canc Ctr, Dept Gynecol Oncol, Kobe, Hyogo, Japan

[12] Saga Univ, Dept Gynecol & Obstet, Saga, Japan

[13] Tottori Univ, Dept Obstet & Gynecol, Tottori, Japan

[14] Shikoku Canc Ctr, Dept Gynecol Oncol, Sapporo, Hokkaido, Japan

[15] Saitama Canc Ctr, Dept Gynecol Oncol, Saitama, Japan

[16] Kure Med Ctr, Dept Gynecol Oncol, Hiroshima, Japan

[17] Juntendo Univ, Sch Med, Dept Obstet & Gynecol, Keio, Japan

[18] Kyushu Univ, Dept Obstet & Gynecol, Fukuoka 812, Japan

[19] Shinshu Univ, Dept Obstet & Gynecol, Matsumoto, Nagano, Japan

[20] Kagoshima City Hosp, Dept Obstet & Gynecol, Kagoshima, Japan

[21] Niigata Canc Ctr Hosp, Dept Gynecol, Tokyo, Japan

[22] Tohoku Univ, Dept Obstet & Gynecol, Sendai, Miyagi 980, Japan

[23] Univ Tsukuba, Dept Obstet & Gynecol, Tsukuba, Ibaraki 305, Japan

[24] Kyoto Univ, Dept Gynecol & Obstet, Kyoto 6068501, Japan

[25] Kurume Univ, Dept Obstet & Gynecol, Kurume, Fukuoka, Japan

来源：

GYNECOLOGIC ONCOLOGY | 2015年 / 137卷 / 01期

关键词：

Cervical cancer; FIGO stage IB1; Radical hysterectomy; Tumor diameter; MR imaging; MODIFIED RADICAL HYSTERECTOMY; COMPUTED-TOMOGRAPHY; CLASS-II; LOW-RISK; CARCINOMA; SURGERY; IDENTIFICATION; LYMPHADENECTOMY; CHEMOTHERAPY; WOMEN;

D O I：

10.1016/j.ygyno.2015.01.548

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective. In order to determine indications for less radical surgery such as modified radical hysterectomy, the risk of pathological parametrial involvement and prognosis of FIGO stage IB1 cervical cancer patients undergoing standard radical hysterectomy with pre-operatively assessed tumor diameter <= 2 cm were investigated. Methods. We conducted a retrospective multi-institutional chart review of patients with FIGO stage IB1 cervical cancer who underwent primary surgical treatment between 1998 and 2002. The eligibility criteria for the analyses were (i) histologically-proven squamous cell carcinoma, adenocarcinoma or, adenosquamous cell carcinoma, (ii) radical hysterectomy performed, (iii) clinical tumor diameter data available by MR imaging or specimens by cone biopsy, and (iv) age between 20 and 70. Based on the clinical tumor diameter, patients were stratified into those with the following tumors: i) 2 cm or less (cT <= 2 cm) and ii) greater than 2 cm (cT > 2 cm). We expected 5-year OS of >= 95% and parametrial involvement <2-3% for patients with cT <= 2 cm who underwent radical hysterectomy. Results. Of the 1269 patients enrolled, 604 were eligible for the planned analyses. Among these, 571 underwent radical hysterectomy (323 with cT <= 2 cm and 248 with cT > 2 cm). Parametrial involvement was present in 1.9% (6/323) with cT <= 2 cm and 12.9% (32/248) with cT > 2 cm. Five-year overall survivals were 95.8% (95% CI 92.9-97.6%) in cT <= 2 cm and 91.9% (95% Cl 87.6-94.8%) in cT > 2 cm patients. Conclusion. Patients with cT <= 2 cm had lower risk of parametrial involvement and more favorable 5-year overall survival. They could therefore be good candidates for receiving less radical surgery. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：34 / 39

页数：6

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