Fertility preservation in young men with Klinefelter syndrome: A systematic review

被引:9
作者
Ly, Anna [1 ]
Sermondade, Nathalie [1 ,2 ]
Brioude, Frederic [3 ]
Berthaut, Isabelle [1 ,2 ]
Bachelot, Anne [4 ]
Hamid, Rahaf Haj [1 ]
El Khattabi, Laila [5 ]
Prades, Marie [1 ]
Levy, Rachel [1 ,2 ]
Dupont, Charlotte [1 ,2 ]
机构
[1] Sorbonne Univ, Hop Tenon, AP HP, Serv Biol Reprod CECOS, 4 Rue Chine, F-75020 Paris, France
[2] Sorbonne Univ, Inserm US938, Ctr Rech St Antoine, F-75012 Paris, France
[3] Sorbonne Univ, Hop Trousseau, AP HP, Explorat Fonctionnelles Endocriniennes, F-75012 Paris, France
[4] Sorbonne Univ, Hop Pitie Salpetriere, AP HP, Serv Endocrinol & Med Reprod,Ctr Reference Malad, F-75013 Paris, France
[5] Univ Paris, Hop Cochin, AP HP Ctr, Serv Cytogenet,Fac Med,Inst Cochin INSERM U1016, F-75014 Paris, France
关键词
Fertility preservation; Klinefelter syndrome; Young men; Adolescent; TESE; Sperm collection; SPERM RETRIEVAL; ADOLESCENTS; EXTRACTION; PUBERTY; BOYS;
D O I
10.1016/j.jogoh.2021.102177
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Background: Klinefelter syndrome (KS) is the most common cause of genetic male infertility, as most patients present azoospermia. In the testis, a massive decrease in the number of germinal cells is observed and this can begin early in childhood. Thus, it is possible to collect spermatozoa after sperm collection or thanks to testicular sperm extraction (TESE), but the chances finding spermatozoa are decreasing with the age. Sperm collection or TESE should be performed as early as possible. When KS is diagnosed during childhood or teens, fertility preservation could be beneficial. The minimal age for proposing fertility preservation remains controversial and there is no current recommendation about fertility preservation in young men with KS. Design: In this context, we have conducted a systematic review of the results of fertility preservation in young patients with KS to discuss the optimal age range for offering fertility preservation, including or not a TESE. Results: Six articles were included in the systematic review, with patients between 13 and 24 years-old. Except for one, all young men agreed for sperm collection following masturbation. Azoospermia was diagnosed in all patients presenting homogenous KS. One study reported the presence of spermatozoa in the ejaculate of a young man with mosaic KS. Fifty-eight young man for whom ejaculated sperm collection was unsuccessful have benefited from TESE. Testicular spermatozoa were found and frozen in 27 patients out of the 58 (46.5%). The chances of freezing viable testicular sperm between 14 and 23 years of age do not appear to depend on age. Conclusion: Fertility preservation should be proposed in young men, but the optimal age for proposing the first sperm collection could be adapted according to the medical context and the psychological maturity of the young man. (C) 2021 Elsevier Masson SAS. All rights reserved.
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页数:5
相关论文
共 21 条
[1]   Predictors of surgical sperm retrieval in non-obstructive azoospermia: summary of current literature [J].
Arshad, Muhammad A. ;
Majzoub, Ahmad ;
Esteves, Sandro C. .
INTERNATIONAL UROLOGY AND NEPHROLOGY, 2020, 52 (11) :2015-2038
[2]   Setting Up a Cryopreservation Programme for Immature Testicular Tissue: Lessons Learned After More Than 15 Years of Experience [J].
Braye, Aude ;
Tournaye, Herman ;
Goossens, Ellen .
CLINICAL MEDICINE INSIGHTS-REPRODUCTIVE HEALTH, 2019, 13
[3]   Sperm recovery and ICSI outcomes in Klinefelter syndrome: a systematic review and meta-analysis [J].
Corona, Giovanni ;
Pizzocaro, Alessandro ;
Lanfranco, Fabio ;
Garolla, Andrea ;
Pelliccione, Fiore ;
Vignozzi, Linda ;
Ferlin, Alberto ;
Foresta, Carlo ;
Jannini, Emmanuele A. ;
Maggi, Mario ;
Lenzi, Andrea ;
Pasquali, Daniela ;
Francavilla, Sandro .
HUMAN REPRODUCTION UPDATE, 2017, 23 (03) :265-275
[4]   Testicular tissue extraction in a young male with 47,XXY Klinefelter's syndrome: Potential strategy for preservation of fertility [J].
Damani, MN ;
Mittal, R ;
Oates, RD .
FERTILITY AND STERILITY, 2001, 76 (05) :1054-1056
[5]   Age-related presence of spermatogonia in patients with Klinefelter syndrome: a systematic review and meta-analysis [J].
Deebel, Nicholas A. ;
Galdon, Guillermo ;
Zarandi, Nima Pourhabibi ;
Stogner-Underwood, Kimberly ;
Howards, Stuart ;
Lovato, James ;
Kogan, Stanley ;
Atala, Anthony ;
Lue, Yanhe ;
Sadri-Ardekani, Hooman .
HUMAN REPRODUCTION UPDATE, 2020, 26 (01) :58-72
[6]   Klinefelter syndrome and fertility: sperm preservation should not be offered to children with Klinefelter syndrome [J].
Franik, S. ;
Hoeijmakers, Y. ;
D'Hauwers, K. ;
Braat, D. D. M. ;
Nelen, W. L. M. ;
Smeets, D. ;
Claahsen-van der Grinten, H. L. ;
Ramos, L. ;
Fleischer, K. .
HUMAN REPRODUCTION, 2016, 31 (09) :1952-1959
[7]   Testicular biopsy and cryopreservation for fertility preservation of prepubertal boys with Klinefelter syndrome: a pro/con debate [J].
Gies, Inge ;
Oates, Robert ;
De Schepper, Jean ;
Tournaye, Herman .
FERTILITY AND STERILITY, 2016, 105 (02) :249-255
[8]   Syndrome characterized by gynecomastisa, aspermatogenesis without a-leydigism, and increased excietion of follicle-stimulating hormone [J].
Klinefelter, HF ;
Reifenstein, EC ;
Albright, F .
JOURNAL OF CLINICAL ENDOCRINOLOGY, 1942, 2 (11) :615-627
[9]   Klinefelter's syndrome [J].
Lanfranco, F ;
Kamischke, A ;
Zitzmann, M ;
Nieschlag, E .
LANCET, 2004, 364 (9430) :273-283
[10]   Successful testicular sperm retrieval in adolescents with Klinefelter syndrome treated with at least 1 year of topical testosterone and aromatase inhibitor [J].
Mehta, Akanksha ;
Bolyakov, Alexander ;
Roosma, Jordan ;
Schlegel, Peter N. ;
Paduch, Darius A. .
FERTILITY AND STERILITY, 2013, 100 (04) :970-974