Autologous Bone Marrow Infusion Activates the Progenitor Cell Compartment in Patients With Advanced Liver Cirrhosis

被引：61

作者：

Kim, Ja Kyung ^{[1
,7
,8
]}

Park, Young Nyun ^{[6
,7
,8
]}

Kim, Jin Seok ^{[1
]}

Park, Mi-Suk ^{[3
,7
]}

Paik, Yong Han ^{[1
,6
,7
,8
]}

Seok, Jae-Yeon ^{[2
]}

Chung, Yong Eun ^{[3
]}

Kim, Hyun Ok ^{[4
]}

Kim, Kyung Sik ^{[5
,7
]}

Ahn, Sang Hoon ^{[1
,7
,8
]}

Kim, Do Young ^{[1
,7
,8
]}

Kim, Myeong-Jin ^{[3
,7
]}

Lee, Kwan Sik ^{[1
,7
,8
]}

Chon, Chae Yoon ^{[1
,7
,8
]}

Kim, Soo Jeong ^{[1
]}

Terai, Shuji ^{[9
]}

Sakaida, Isao ^{[9
]}

Han, Kwang-Hyub ^{[1
,6
,7
,8
]}

机构：

[1] Yonsei Univ, Coll Med, Dept Internal Med, Seoul 120752, South Korea

[2] Yonsei Univ, Coll Med, Dept Pathol, Seoul 120752, South Korea

[3] Yonsei Univ, Coll Med, Dept Radiol, Seoul 120752, South Korea

[4] Yonsei Univ, Coll Med, Dept Lab Med, Seoul 120752, South Korea

[5] Yonsei Univ, Coll Med, Dept Surg, Seoul 120752, South Korea

[6] Yonsei Univ, Coll Med, BK Project Med Sci 21, Seoul 120752, South Korea

[7] Yonsei Univ, Coll Med, Yonsei Inst Gastroenterol, Seoul 120752, South Korea

[8] Liver Cirrhosis Clin Res Ctr, Seoul, South Korea

[9] Yamaguchi Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Yamaguchi, Japan

来源：

CELL TRANSPLANTATION | 2010年 / 19卷 / 10期

关键词：

Adult bone marrow stem cell; Autologous bone marrow transplantation; Liver cirrhosis; Liver regeneration; Progenitor cell; HEMATOPOIETIC STEM-CELLS; HEPATIC OVAL CELLS; IN-VIVO; INJURED LIVER; HEPATOCYTES; REGENERATION; TRANSPLANTATION; FIBROSIS; DIFFERENTIATION; PLASTICITY;

D O I：

10.3727/096368910X506863

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Several clinical trials of bone marrow cell infusion in patients with liver cirrhosis (LC) have shown clinical improvement, despite conflicting results from animal models. We investigated serial pathological features and the clinical impact after autologous bone marrow infusion (ABM1) in patients with advanced LC. Ten patients with advanced LC due to chronic hepatitis B virus infection underwent ABMI. Serological tests, MRI, and liver biopsies were performed, and quality of life was assessed by a questionnaire. Median serum albumin and hemoglobin levels increased significantly after ABM1. All patients showed an improvement in quality of life, with no serious adverse events. Liver volume, measured by MRI, increased in 80% of the patients, and ascites decreased after ABMI. Child-Pugh scores were also significantly improved at 6 months after ABMI. In the serially biopsied livers, a gradually increasing activation of the hepatic progenitor cell (HPC) compartment, including HPC activation (ductular reaction) and HPC differentiation (intermediate hepatocyte), reached a peak after 3 months, with continued proliferation of hepatocytes, and returned to baseline levels after 6 months. There was no significant change in grade or stage of liver fibrosis or stellate cell activation after ABMI. ABMI is suggested to improve liver function and to activate the progenitor cell compartment. Although clinical improvement was sustained for more than 6 months, histological changes in the liver returned to baseline 6 months after ABMI. Further comparative studies are warranted.

引用

页码：1237 / 1246

页数：10

共 31 条

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