Ten questions for evolutionary studies of disease vulnerability

被引：39

作者：

Nesse, Randolph M. ^{[1
,2
]}

机构：

[1] Univ Michigan, Inst Social Res, Dept Psychiat, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Inst Social Res, Dept Psychol, Ann Arbor, MI 48109 USA

来源：

EVOLUTIONARY APPLICATIONS | 2011年 / 4卷 / 02期

基金：

美国国家科学基金会;

关键词：

Darwinian medicine; disease; evolutionary medicine; hypothesis testing; methodology; vulnerability; DEGENERATIVE DISEASES; CYSTIC-FIBROSIS; URIC-ACID; ADAPTATION; CANCER; SCHIZOPHRENIA; SELECTION; BIOLOGY; PERSPECTIVES; POPULATION;

D O I：

10.1111/j.1752-4571.2010.00181.x

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Many evolutionary applications in medicine rely on well-established methods, such as population genetics, phylogenetic analysis, and observing pathogen evolution. Approaches to evolutionary questions about traits that leave bodies vulnerable to disease are less well developed. Strategies for formulating questions and hypotheses remain unsettled, and methods for testing evolutionary hypotheses are unfamiliar to many in medicine. This article uses recent examples to illustrate successful strategies and some common challenges. Ten questions arise in the course of considering hypotheses about traits that leave bodies vulnerable to disease. Addressing them systematically can help minimize confusion and errors.

引用

页码：264 / 277

页数：14

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