New α-pyrones produced by fungal culture LL-11G219 function as androgen receptor ligands

被引：66

作者：

Schlingmann, G ^{[1
]}

Milne, L ^{[1
]}

Carter, GT ^{[1
]}

机构：

[1] Wyeth Ayerst Res, Natl Prod Chem, Pearl River, NY 10965 USA

来源：

TETRAHEDRON | 1998年 / 54卷 / 43期

关键词：

natural products; pyrones; biologically active compounds; fungi;

D O I：

10.1016/S0040-4020(98)00792-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This report describes the isolation and characterization of several closely related compounds, produced by fungal culture LL-11G219, with androgen-like activity. Bioassay-guided isolation yielded four novel fermentation products of the alpha-pyrone class: 11G219 alpha, beta, gamma, and delta. Structures were assigned to these compounds on the basis of spectroscopic data, particularly those from 1D and 2D MMR experiments, alpha-Pyrones bearing an olefinic side chain in conjunction with a 6-alkyl substitution were hitherto unknown. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：13013 / 13022

页数：10

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