Advanced palladium free approach to the synthesis of substituted alkene oxindoles via aluminum-promoted Knoevenagel reaction

被引：13
作者：
Novikova, Daria S. [1 ]
Grigoreva, Tatyana A. [1 ]
Zolotarev, Andrey A. [2 ]
Garabadzhiu, AlexanderV. [1 ]
Tribulovich, Vyacheslav G. [1 ]
机构：
[1] Tech Univ, St Petersburg State Inst Technol, Lab Mol Pharmacol, Moskovskii Pr 26, St Petersburg 190013, Russia
[2] St Petersburg State Univ, Dept Crystallog, Per Dekabristov 16, St Petersburg 199155, Russia
来源：
RSC ADVANCES | 2018年 / 8卷 / 60期
基金：
俄罗斯科学基金会;
关键词：
ACTIVATED PROTEIN-KINASE; AMPK; DERIVATIVES; INHIBITORS; TARGET; DRUGS; CONDENSATION; RECEPTOR; CANCER;
D O I：
10.1039/c8ra07576j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A synthetic route for the synthesis of C24, as well as for the design of focused libraries of direct AMPK activators was developed based on a convergent strategy. The proposed scheme corresponds to the current trends in C-H bond functionalization. The use of aluminum isopropoxide for the Knoevenagel condensation of oxindole with benzophenones is a noticeable point of this work.
引用
收藏
页码：34543 / 34551
页数：9
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