Advanced palladium free approach to the synthesis of substituted alkene oxindoles via aluminum-promoted Knoevenagel reaction

被引：13

作者：

Novikova, Daria S. ^{[1
]}

Grigoreva, Tatyana A. ^{[1
]}

Zolotarev, Andrey A. ^{[2
]}

Garabadzhiu, AlexanderV. ^{[1
]}

Tribulovich, Vyacheslav G. ^{[1
]}

机构：

[1] Tech Univ, St Petersburg State Inst Technol, Lab Mol Pharmacol, Moskovskii Pr 26, St Petersburg 190013, Russia

[2] St Petersburg State Univ, Dept Crystallog, Per Dekabristov 16, St Petersburg 199155, Russia

来源：

RSC ADVANCES | 2018年 / 8卷 / 60期

基金：

俄罗斯科学基金会;

关键词：

ACTIVATED PROTEIN-KINASE; AMPK; DERIVATIVES; INHIBITORS; TARGET; DRUGS; CONDENSATION; RECEPTOR; CANCER;

D O I：

10.1039/c8ra07576j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A synthetic route for the synthesis of C24, as well as for the design of focused libraries of direct AMPK activators was developed based on a convergent strategy. The proposed scheme corresponds to the current trends in C-H bond functionalization. The use of aluminum isopropoxide for the Knoevenagel condensation of oxindole with benzophenones is a noticeable point of this work.

引用

页码：34543 / 34551

页数：9

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