Evaluation of Traditional Prognostic Factors for Stage I-III Colorectal Cancer Patients Who Survived for Over Five Years After Surgery

被引:2
作者
Luo, Dakui [1 ,2 ]
Yang, Yufei [1 ,2 ]
Shan, Zezhi [1 ,2 ]
Liu, Qi [1 ,2 ]
Cai, Sanjun [1 ,2 ]
Li, Qingguo [1 ,2 ]
Li, Xinxiang [1 ,2 ]
机构
[1] Fudan Univ, Dept Colorectal Surg, Shanghai Canc Ctr, Shanghai, Peoples R China
[2] Fudan Univ, Dept Oncol, Shanghai Med Coll, Shanghai, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2021年 / 11卷
基金
中国国家自然科学基金;
关键词
colorectal cancer; survive over five years; prognostic factors; FUSCC; COX; COLON-CANCER;
D O I
10.3389/fonc.2021.618820
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The aim of this study was to explore the prognostic factors in stage I-III colorectal cancer (CRC) patients who had survived for over five years. A total of 9754 stage I-III CRC patients who received curative surgery in the Department of Colorectal Surgery, Fudan University Shanghai Cancer Center were enrolled in this study. Of them, 3640 patients had survived for over five years after surgery. Univariate and multivariate Cox regression analyses were performed in the entire cohort and those who had survived for over five years. Compared with patients in the entire cohort, patients who had survived for over five years were more likely to be younger, have less disease of signet ring cell histology, perineural invasion and vascular invasion, more well differentiated tumors and stage I disease. In the entire cohort, increased age, signet ring cell, poor differentiation, more advanced pathological stage, perineural invasion and vascular invasion were inversely associated with disease-free survival (DFS) and overall survival (OS) using multivariable Cox regression analyses. Only age, pathological stage and perineural invasion remained significant in patients who had survived for over five years. Moreover, tumor location was an independent factor for OS in this subgroup. Predictors for prognosis of CRC change over time. Age, pathological stage and perineural invasion deserve more attention among patients who have survived for over five years.
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页数:7
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共 17 条
  • [1] The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population-based to a more "personalized" approach to cancer staging
    Amin, Mahul B.
    Greene, Frederick L.
    Edge, Stephen B.
    Compton, Carolyn C.
    Gershenwald, Jeffrey E.
    Brookland, Robert K.
    Meyer, Laura
    Gress, Donna M.
    Byrd, David R.
    Winchester, David P.
    [J]. CA-A CANCER JOURNAL FOR CLINICIANS, 2017, 67 (02) : 93 - 99
  • [2] Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer
    Andre, T
    Boni, C
    Mounedji-Boudiaf, L
    Navarro, M
    Tabernero, J
    Hickish, T
    Topham, C
    Zaninelli, M
    Clingan, P
    Bridgewater, J
    Tabah-Fisch, I
    de Gramont, A
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (23) : 2343 - 2351
  • [3] Incidence and patterns of late recurrences in colon cancer patients
    Bouvier, Anne-Marie
    Launoy, Guy
    Bouvier, Veronique
    Rollot, Fabien
    Manfredi, Sylvain
    Faivre, Jean
    Cottet, Vanessa
    Jooste, Valerie
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2015, 137 (09) : 2133 - 2138
  • [4] A critical reappraisal for the value of tumor size as a prognostic variable in rectal adenocarcinoma
    Chen, Chien-Hsin
    Hsieh, Mao-Chih
    Hsiao, Ping-Kun
    Lin, En-Kwang
    Lu, Yen-Jung
    Wu, Szu-Yuan
    [J]. JOURNAL OF CANCER, 2017, 8 (10): : 1927 - 1934
  • [5] Prognostic Factors Five Years After Enucleation for Uveal Melanoma
    Dogrusoz, Mehmet
    Brouwer, Niels J.
    de Geus, Stefan J. R.
    Ly, Long, V
    Bohringer, Stefan
    van Duinen, Sjoerd G.
    Kroes, Wilma G. M.
    van der Velden, Pieter A.
    Haasnoot, Geert W.
    Marinkovic, Marina
    Luyten, Gregorius P. M.
    Kivela, Tero T.
    Jager, Martine J.
    [J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2020, 61 (03)
  • [6] Prospective evaluation of prognostic factors in patients with colorectal cancer undergoing curative resection
    Fujita, S
    Shimoda, T
    Yoshimura, K
    Yamamoto, S
    Akasu, T
    Moriya, Y
    [J]. JOURNAL OF SURGICAL ONCOLOGY, 2003, 84 (03) : 127 - 131
  • [7] Colorectal Cancer in Young Adults
    Inra, Jennifer A.
    Syngal, Sapna
    [J]. DIGESTIVE DISEASES AND SCIENCES, 2015, 60 (03) : 722 - 733
  • [8] Tumor budding and poorly-differentiated cluster in prognostication in Stage II colon cancer
    Lee, Victor Wai Kwan
    Chan, Kui Fat
    [J]. PATHOLOGY RESEARCH AND PRACTICE, 2018, 214 (03) : 402 - 407
  • [9] Is the AJCC TNM staging system still appropriate for gastric cancer patients survival after 5 years?
    Lin, Jian-Xian
    Lin, Jun-Peng
    Xie, Jian-Wei
    Wang, Jia-Bin
    Lu, Jun
    Chen, Qi-Yue
    Cao, Long-Long
    Lin, Mi
    Tu, Ru-Hong
    Zheng, Chao-Hui
    Huang, Chang-Ming
    Li, Ping
    [J]. EJSO, 2019, 45 (06): : 1115 - 1120
  • [10] Assessing the prognostic value of carcinoembryonic antigen levels in stage I and II colon cancer
    Margalit, Ofer
    Mamtani, Ronac
    Yang, Yu-Xiao
    Reiss, Kim A.
    Golan, Talia
    Halpern, Naama
    Aderka, Dan
    Giantonio, Bruce
    Shacham-Shmueli, Einat
    Boursi, Ben
    [J]. EUROPEAN JOURNAL OF CANCER, 2018, 94 : 1 - 5