Management of antipsychotic-induced constipation requires more attention

被引:0
作者
Blair, Hannah A. [1 ]
机构
[1] Springer Nat, Private Bag 65901, Auckland 0754, New Zealand
关键词
INDUCED GASTROINTESTINAL HYPOMOTILITY; CLOZAPINE;
D O I
10.1007/s40267-022-00935-5
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Constipation is a common adverse effect of antipsychotic therapy that remains understudied and underreported. Weekly constipation screening, continuous long-term monitoring, reducing the antipsychotic dose and switching to a different antipsychotic with less risk of constipation are useful preventive measures. Recommended options for the treatment of antipsychotic-induced constipation include lifestyle changes, behavioural therapy, laxatives and novel drugs (e.g. lubiprostone, prucalopride). Patients who are refractory to pharmacological treatment may be candidates for surgery.
引用
收藏
页码:356 / 361
页数:6
相关论文
共 23 条
  • [1] Factors predicting use of laxatives in outpatients stabilized on clozapine
    Bailey, Loren
    Varma, Seema
    Ahmad, Nina
    Gee, Siobhan
    Taylor, David M.
    [J]. THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY, 2015, 5 (05) : 256 - 262
  • [2] American Gastroenterological Association Medical Position Statement on Constipation
    Bharucha, Adil E.
    Dorn, Spencer D.
    Lembo, Anthony
    Pressman, Amanda
    [J]. GASTROENTEROLOGY, 2013, 144 (01) : 211 - 217
  • [3] Chronic constipation
    Camilleri, Michael
    Ford, Alexander C.
    Mawe, Gary M.
    Dinning, Phil G.
    Rao, Satish S.
    Chey, William D.
    Simren, Magnus
    Lembo, Anthony
    Young-Fadok, Tonia M.
    Chang, Lin
    [J]. NATURE REVIEWS DISEASE PRIMERS, 2017, 3
  • [4] Prevalence and Factors Associated With Clozapine-Related Constipation An Observational Study
    Chougule, Amitkumar
    Praharaj, Samir Kumar
    Bhat, Shripathy M.
    Sharma, P. S. V. N.
    [J]. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2018, 38 (01) : 42 - 46
  • [5] An Open-Label, Head to Head Comparison Study between Prucalopride and Lactulose for Clozapine Induced Constipation in Patients with Treatment Resistant Schizophrenia
    Damodaran, Ishwary
    Hui, Koh Ong
    Nordin, Amer Siddiq Amer
    Yee, Anne
    Gill, Jesjeet Singh
    Francis, Benedict
    Azhar, Fatin Liyana
    Sulaiman, Ahmad Hatim
    [J]. HEALTHCARE, 2020, 8 (04)
  • [6] Challenges associated with treating and preventing antipsychotic-induced constipation: considerations and cautions when prescribing novel interventions
    Demler, Tammie Lee
    Krieger, Kelly
    [J]. INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 2021, 36 (01) : 12 - 17
  • [7] Clozapine-Induced Gastrointestinal Hypomotility: A 22-Year Bi-National Pharmacovigilance Study of Serious or Fatal 'Slow Gut' Reactions, and Comparison with International Drug Safety Advice
    Every-Palmer, Susanna
    Ellis, Pete M.
    [J]. CNS DRUGS, 2017, 31 (08) : 699 - 709
  • [8] Spatiotemporal Mapping Techniques Show Clozapine Impairs Neurogenic and Myogenic Patterns of Activity in the Colon of the Rabbit in a Dose-Dependent Manner
    Every-Palmer, Susanna
    Lentle, Roger G.
    Reynolds, Gordon
    Hulls, Corrin
    Chambers, Paul
    Dunn, Helen
    Ellis, Pete M.
    [J]. FRONTIERS IN PHARMACOLOGY, 2017, 8
  • [9] Pharmacological Treatment for Antipsychotic-Related Constipation
    Every-Palmer, Susanna
    Newton-Howes, Giles
    Clarke, Mike J.
    [J]. SCHIZOPHRENIA BULLETIN, 2017, 43 (03) : 490 - 492
  • [10] Clozapine-induced stercoral colitis: a surgical perspective
    George, Jayan
    Hotham, Richard
    Melton, William
    Chapple, Keith
    [J]. BMJ CASE REPORTS, 2019, 12 (08)