Coumarins isolated from Angelica gigas inhibit acetylcholinesterase:: Structure-activity relationships

被引：211

作者：

Kang, SY ^{[1
]}

Lee, KY ^{[1
]}

Sung, SH ^{[1
]}

Park, MJ ^{[1
]}

Kim, YC ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 05期

关键词：

D O I：

10.1021/np000441w

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Acetylcholinesterase (AChE) inhibitory activity-guided fractionation of Angelica gigas led to isolation and identification of a new coumarin, peucedanone (12), and isolation of 11 known coumarins. Among them, decursinol (1) represented the highest inhibitory activity toward AChE in vitro. The correlation of the inhibitory activities of the coumarins toward AChE with their chemical structures was studied.

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页码：683 / 685

页数：3

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