Microwave-assisted synthesis of substituted 2,4-diarylthiazoles and their evaluation as anticancer agents

被引：5
|
作者：
Romagnoli, Romeo
Baraldi, Pier Giovanni
Lopez, Olga Cruz
Carrion, Maria Dora
Cara, Carlota Lopez
Preti, Delia
Tabrizi, Moigan Aghazadeh
Balzarini, Jan
机构：
[1] Univ Ferrara, Dipartimento Sci Farmaceut, I-44100 Ferrara, Italy
[2] Rega Inst, Lab Virol & Chemotherapy, B-3000 Louvain, Belgium
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2007年 / 4卷 / 07期
关键词：
microwave; thiazole; anticancer agents;
D O I：
10.2174/157018007781788507
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The microwave-promoted cyclization method has been used for the synthesis of a series of novel Substituted 2,4-diarylthiazoles from alpha-halo ketones and thioamides using ethanol as solvent. This rapid method produces compounds in good yield within one minute in comparison with conventional heating method. The synthesized molecules have been evaluated for their antiproliferative effects against five different cancer cell lines.
引用
收藏
页码：464 / 466
页数：3
相关论文
共 50 条
  • [1] Nuclear fluorination of 2,4-diarylthiazoles with Accufluor®
    Campbell, Timmeda F.
    Stephens, Chad E.
    JOURNAL OF FLUORINE CHEMISTRY, 2006, 127 (12) : 1591 - 1594
  • [2] Synthesis of 2,4-diarylthiazoles throuth palladium-catalyzed cyclization of sulfoxonium ylides and benzothioamide
    Lu, Yi-Xuan
    Zhu, Liang-Wei
    Lv, Ting-kang
    Chen, Bao-Hua
    TETRAHEDRON LETTERS, 2022, 105
  • [3] Microwave-assisted synthesis of certain pyrrolylpyridines, some derived ring systems and their evaluation as anticancer and antioxidant agents
    Rostom, Sherif A. F.
    Bekhit, Adnan A.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 92 : 712 - 722
  • [4] Microwave-assisted synthesis of N-substituted cyclic imides and their evaluation for anticancer and anti-inflammatory activities
    Sondhi, Sham M.
    Rani, Reshma
    Roy, Partha
    Agrawal, S. K.
    Saxena, A. K.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (05) : 1534 - 1538
  • [5] Microwave-assisted synthesis and biological evaluation of thiazole-substituted dibenzofurans
    Baba, N. H. Kumar
    Ashok, D.
    Rao, Boddu Ananda
    Madderla, Sarasija
    Murthy, N. Y. S.
    HETEROCYCLIC COMMUNICATIONS, 2018, 24 (03) : 171 - 176
  • [6] Microwave-assisted synthesis and evaluation of indole derivatives as potential anthelmintic agents
    Panda, Jnyanaranjan
    Kumar, Anjan
    Sahoo, Biswa Mohan
    Banik, Bimal Krishna
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 2018, 95 (11) : 1283 - 1288
  • [7] Microwave-assisted synthesis of novel Ti/BTB-MOFs as porous anticancer and antibacterial agents
    Altharawi, Ali
    Alqahtani, Safar M.
    Aldakhil, Taibah
    Ahmad, Irfan
    FRONTIERS IN CHEMISTRY, 2024, 12
  • [8] Microwave-assisted synthesis of substituted 1,2,4-triazoles
    Wu, Dong-Qing
    He, Jian-Li
    Wang, Jun-Ke
    Wang, Xi-Cun
    Zong, Ying-Xiao
    JOURNAL OF CHEMICAL RESEARCH-S, 2006, (05): : 293 - 294
  • [9] Microwave-Assisted Synthesis and Evaluation of Substituted Aryl Propyl Acridone-4-Carboxamides as Potential Chemosensitizing Agents for Cancer
    Velingkar, Vinaykumar S.
    Dandekar, Vikrant D.
    LETTERS IN DRUG DESIGN & DISCOVERY, 2011, 8 (03) : 268 - 275
  • [10] Microwave-assisted synthesis of benzenesulfonohydrazide and benzenesulfonamide cyclic imide hybrid molecules and their evaluation for anticancer activity
    Anuj Kumar
    Nikhil Kumar
    Partha Roy
    S. M. Sondhi
    Anuj Sharma
    Medicinal Chemistry Research, 2015, 24 : 3760 - 3771
12345