Opioid Peptide Deltorphin II Simulates the Cardioprotective Effect of Ischemic Preconditioning: Role of δ2-Opioid Receptors, Protein Kinase C, and KATP Channels

被引：9
|
作者：
Maslov, L. N. [1 ,2 ]
Barzakh, E. I. [3 ]
Krylatov, A. V. [1 ,2 ]
Chernysheva, G. A. [4 ]
Krieg, T. [5 ]
Solenkova, N. V. [6 ]
Lishmanov, A. Yu. [1 ]
Tsibulnikov, S. Yu. [1 ,2 ]
Zhang, Y. [7 ]
机构：
[1] Russian Acad Med Sci, Inst Cardiol, Siberian Div, Tomsk, Russia
[2] Tomsk State Pedag Univ, Tomsk, Russia
[3] Jewish Univ, Jerusalem, Israel
[4] Russian Acad Med Sci, Inst Pharmacol, Siberian Div, Tomsk, Russia
[5] Ernst Moritz Arndt Univ Greifswald, D-17487 Greifswald, Germany
[6] Vanderbilt Univ, Nashville, TN USA
[7] Anhui Med Univ, Hefei, Peoples R China
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2010年 / 149卷 / 05期
基金：
俄罗斯基础研究基金会;
关键词：
heart; ischemia/reperfusion; opioid receptors; protein kinase C; K-ATP channels; INFARCT SIZE; MITOCHONDRIAL; ACTIVATION;
D O I：
10.1007/s10517-010-1000-6
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The cardioprotective properties of a delta(2)-opioid receptor agonist deltorphin II were studied in rats with coronary occlusion and reperfusion. Opioid receptor ligands and inhibitors (glybenclamide, chelerythrine, and 5-hydroxydecanoate) were injected intravenously before ischemia and reperfusion. A delta(2)-opioid receptor agonist deltorphin II significantly decreased the infarction zone/risk zone index. This effect was abolished by naltrexone, naloxone methiodide, and delta(2)-opioid receptor antagonist naltriben, but not by a delta(1)-opioid receptor antagonist BNTX. The infarct-limiting effect of deltorphin II was not observed after inhibition of protein kinase C or blockade of mitochondrial K-ATP channels.
引用
收藏
页码：591 / 593
页数：3
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