How cells respond to interferons revisited: From early history to current complexity

被引：142

作者：

Stark, George R. ^{[1
]}

机构：

[1] Cleveland Clin, Dept Mol Genet, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Dept Genet, Cleveland, OH USA

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2007年 / 18卷 / 5-6期

关键词：

interferons; STATs; JAKs;

D O I：

10.1016/j.cytogfr.2007.06.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A brief account of how I became involved in interferon research is followed by recollections of key experiments that led to the discovery of the roles of the JAKs and STATs in interferon-dependent signaling. I then outline the complex responses of cells to interferons, including the roles of kinases other than JAKs and transcription factors other than STATs, differential responses to interferons alpha and beta, modulation of response by prior exposure to other cytokines ("priming"), cytokine-dependent induction of high level expression of STATs I and 3 and the activation of a new set of genes by these unphosphorylated STATs, and diverse patterns of STAT activation in different cell types in response to a single interferon. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：419 / 423

页数：5

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