Organizing signal transduction through A-kinase anchoring proteins (AKAPs)

被引：35
作者：
Logue, Jeremy S. [1 ,2 ,3 ]
Scott, John D. [1 ,2 ]
机构：
[1] Univ Washington, Sch Med, Howard Hughes Med Inst, Seattle, WA 98195 USA
[2] Univ Washington, Sch Med, Dept Pharmacol, Seattle, WA 98195 USA
[3] Univ Washington, Mol & Cellular Biol Program, Seattle, WA 98195 USA
来源：
FEBS JOURNAL | 2010年 / 277卷 / 21期
基金：
美国国家卫生研究院;
关键词：
AKAP; cAMP; enzyme complexes; signal transduction; RHO-GEF ACTIVITY; CARDIAC-HYPERTROPHY; PKA; CHANNEL; PHOSPHORYLATION; LOCALIZATION; SPECIFICITY; ANTAGONIST; ACTIVATION; COMPLEXES;
D O I：
10.1111/j.1742-4658.2010.07866.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A fundamental role for protein-protein interactions in the organization of signal transduction pathways is evident. Anchoring, scaffolding and adapter proteins function to enhance the precision and directionality of these signaling events by bringing enzymes together. The cAMP signaling pathway is organized by A-kinase anchoring proteins. This family of proteins assembles enzyme complexes containing the cAMP-dependent protein kinase, phosphoprotein phosphatases, phosphodiesterases and other signaling effectors to optimize cellular responses to cAMP and other second messengers. Selected A-kinase anchoring protein signaling complexes are highlighted in this minireview.
引用
收藏
页码：4370 / 4375
页数：6
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