Organizing signal transduction through A-kinase anchoring proteins (AKAPs)

被引：35
作者：
Logue, Jeremy S. [1 ,2 ,3 ]
Scott, John D. [1 ,2 ]
机构：
[1] Univ Washington, Sch Med, Howard Hughes Med Inst, Seattle, WA 98195 USA
[2] Univ Washington, Sch Med, Dept Pharmacol, Seattle, WA 98195 USA
[3] Univ Washington, Mol & Cellular Biol Program, Seattle, WA 98195 USA
来源：
FEBS JOURNAL | 2010年 / 277卷 / 21期
基金：
美国国家卫生研究院;
关键词：
AKAP; cAMP; enzyme complexes; signal transduction; RHO-GEF ACTIVITY; CARDIAC-HYPERTROPHY; PKA; CHANNEL; PHOSPHORYLATION; LOCALIZATION; SPECIFICITY; ANTAGONIST; ACTIVATION; COMPLEXES;
D O I：
10.1111/j.1742-4658.2010.07866.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A fundamental role for protein-protein interactions in the organization of signal transduction pathways is evident. Anchoring, scaffolding and adapter proteins function to enhance the precision and directionality of these signaling events by bringing enzymes together. The cAMP signaling pathway is organized by A-kinase anchoring proteins. This family of proteins assembles enzyme complexes containing the cAMP-dependent protein kinase, phosphoprotein phosphatases, phosphodiesterases and other signaling effectors to optimize cellular responses to cAMP and other second messengers. Selected A-kinase anchoring protein signaling complexes are highlighted in this minireview.
引用
收藏
页码：4370 / 4375
页数：6
相关论文
共 36 条
  • [1] Bioinformatic design of A-kinase anchoring protein-in silico:: A potent and selective peptide antagonist of type II protein kinase A anchoring
    Alto, NM
    Soderling, SH
    Hoshi, N
    Langeberg, LK
    Fayos, R
    Jennings, PA
    Scott, JD
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (08) : 4445 - 4450
  • [2] Leucine zipper-mediated homo-oligomerization regulates the Rho-GEF activity of AKAP-Lbc
    Baisamy, L
    Jurisch, N
    Diviani, D
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (15) : 15405 - 15412
  • [3] Delineation of type I protein kinase A-selective signaling events using an RI anchoring disruptor
    Carlson, Cathrine Rein
    Lygren, Birgitte
    Berge, Torunn
    Hoshi, Naoto
    Wong, Wei
    Tasken, Kjetil
    Scott, John D.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (30) : 21535 - 21545
  • [4] AKAP-Lbc nucleates a protein kinase D activation scaffold
    Carnegie, GK
    Smith, FD
    McConnachie, G
    Langeberg, LK
    Scott, JD
    [J]. MOLECULAR CELL, 2004, 15 (06) : 889 - 899
  • [5] AKAP-Lbc Mobilizes a Cardiac Hypertrophy Signaling Pathway
    Carnegie, Graeme K.
    Soughayer, Joseph
    Smith, F. Donelson
    Pedroja, Benjamin S.
    Zhang, Fang
    Diviani, Dario
    Bristow, Michael R.
    Kunkel, Maya T.
    Newton, Alexandra C.
    Langeberg, Lorene K.
    Scott, John D.
    [J]. MOLECULAR CELL, 2008, 32 (02) : 169 - 179
  • [6] CARR DW, 1991, J BIOL CHEM, V266, P14188
  • [7] SUBCELLULAR TARGETING OF KINASES AND PHOSPHATASES BY ASSOCIATION WITH BIFUNCTIONAL ANCHORING PROTEINS
    COGHLAN, VM
    HAUSKEN, ZE
    SCOTT, JD
    [J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 1995, 23 (03) : 592 - 596
  • [8] Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex
    Colledge, M
    Dean, RA
    Scott, GK
    Langeberg, LK
    Huganir, RL
    Scott, JD
    [J]. NEURON, 2000, 27 (01) : 107 - 119
  • [9] A β2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav1.2
    Davare, MA
    Avdonin, V
    Hall, DD
    Peden, EM
    Burette, A
    Weinberg, RJ
    Horne, MC
    Hoshi, T
    Hell, JW
    [J]. SCIENCE, 2001, 293 (5527) : 98 - 101
  • [10] Specific phosphorylation of a site in the full-length form of the alpha 1 subunit of the cardiac L-type calcium channel by adenosine 3',5'-cyclic monophosphate-dependent protein kinase
    DeJongh, KS
    Murphy, BJ
    Colvin, AA
    Hell, JW
    Takahashi, M
    Catterall, WA
    [J]. BIOCHEMISTRY, 1996, 35 (32) : 10392 - 10402
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