Perfluorocarbon nanomaterials for photodynamic therapy

被引：30

作者：

Day, Rachael A. ^{[1
]}

Sletten, Ellen M. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

来源：

CURRENT OPINION IN COLLOID & INTERFACE SCIENCE | 2021年 / 54卷

关键词：

Perfluorocarbon; Fluorous; Photodynamic therapy; Singlet oxygen; Nanoemulsion; Micelle; TUMOR HYPOXIA; OXYGEN; TRANSPORT; PHOTOSENSITIZERS; NANOPARTICLES; OVERCOME;

D O I：

10.1016/j.cocis.2021.101454

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Photodynamic therapy (PDT) is a treatment modality in which a photosensitizer is irradiated with light, producing reactive oxygen species, often via energy transfer with oxygen. As it is common for tumors to be hypoxic, methods to deliver photo sensitizer and oxygen are desirable. One such approach is the use of perfluorocarbons, molecules in which all C-H bonds are replaced with C-F bonds, to co-deliver oxygen because of the high solubility of gases in perfluorocarbons. This review highlights the benefits and limitations of several fluorinated nano material architectures for use in PDT.

引用

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