Development and applications of photo-triggered theranostic agents

被引：420
作者：
Rai, Prakash [1 ]
Mallidi, Srivalleesha [1 ]
Zheng, Xiang [1 ]
Rahmanzadeh, Ramtin [1 ]
Mir, Youssef [1 ]
Elrington, Stefan [1 ]
Khurshid, Ahmat [1 ,3 ]
Hasan, Tayyaba [1 ,2 ]
机构：
[1] Harvard Univ, Wellman Ctr Photomed, Massachusetts Gen Hosp, Sch Med, Boston, MA 02114 USA
[2] Harvard MIT, Boston, MA USA
[3] Pakistan Inst Engn & Appl Sci, Dept Phys & Appl Math, Islamabad, Pakistan
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2010年 / 62卷 / 11期
基金：
美国国家卫生研究院;
关键词：
Photodynamic therapy; Nanotechnology; Photothermal therapy; Cancer; Infections; Imaging; Diagnostics; Targeting; Multifunctional; Drug delivery; GROWTH-FACTOR RECEPTOR; PHASE-II TRIAL; PHOTODYNAMIC THERAPY; QUANTUM DOTS; GOLD NANOSHELLS; DRUG-DELIVERY; CANCER-CELLS; PHOTOTHERMAL THERAPY; TARGETED DELIVERY; CARBON NANOTUBES;
D O I：
10.1016/j.addr.2010.09.002
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Theranostics, the fusion of therapy and diagnostics for optimizing efficacy and safety of therapeutic regimes, is a growing field that is paving the way towards the goal of personalized medicine for the benefit of patients. The use of light as a remote-activation mechanism for drug delivery has received increased attention due to its advantages in highly specific spatial and temporal control of compound release. Photo-triggered theranostic constructs could facilitate an entirely new category of clinical solutions which permit early recognition of the disease by enhancing contrast in various imaging modalities followed by the tailored guidance of therapy. Finally, such theranostic agents could aid imaging modalities in monitoring response to therapy. This article reviews recent developments in the use of light-triggered theranostic agents for simultaneous imaging and photoactivation of therapeutic agents. Specifically, we discuss recent developments in the use of theranostic agents for photodynamic-, photothermal- or photo-triggered chemotherapy for several diseases. Published by Elsevier B.V.
引用
收藏
页码：1094 / 1124
页数：31
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