Comparison of models for describing multiple peaks in solubility profiles

被引：247
作者：
Jouyban-Gharamaleki, A
Acree, WE [1 ]
机构：
[1] Univ N Texas, Dept Chem, Denton, TX 76203 USA
[2] Tabriz Univ Med Sci, Sch Pharm, Dept Pharmaceut Chem, Tabriz 51664, Iran
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1998年 / 167卷 / 1-2期
关键词：
solubility; solvent mixtures; chameleonic effect; combined nearly ideal binary solvent Redlich-Kister; two solubility maxima;
D O I：
10.1016/S0378-5173(98)00073-8
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A model derived from the combined nearly ideal binary solvent/Redlich-Kister equation (CNIBS/R-K) for reproducing the experimental solubility curve in mixed solvent systems showing two solubility maxima is presented. The model's ability to correlate experimental solubility data is compared with those of two previously published empirical models. Computations indicate that the descriptive capability of the CNIBS/R-K model is significantly better than that of both empirical models. The mathematical representation of solute solubility at different temperatures using the CNIBS/R-K model is also considered. (C) 1998 Elsevier Science B.V. All rights reserved.
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页码：177 / 182
页数：6
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