Optical properties of chlorin e6 in living melanoma cells

被引：0

作者：

Dadadzhanova, Antonina, I ^{[1
,2
]}

Kolesova, Ekaterina P. ^{[1
]}

Maslov, Vladimir G. ^{[1
]}

Amar-Lewis, Eliz ^{[2
]}

Goldbart, Riki ^{[2
]}

Traitel, Tamar ^{[2
]}

Kost, Joseph ^{[2
]}

Orlova, Anna O. ^{[1
]}

机构：

[1] ITMO Univ, 14 Birzhevaya Linya VO, St Petersburg 199034, Russia

[2] Ben Gurion Univ Negev, David Ben Gurion Blvd, IL-84105 Beer Sheva, Israel

来源：

BIOMEDICAL SPECTROSCOPY, MICROSCOPY, AND IMAGING | 2020年 / 11359卷

关键词：

sensitizer; Chlorin e6; aggregation; monomers; singlet oxygen; cancer; Photodynamic therapy; optical properties; spectroscopy; PHOTODYNAMIC THERAPY; SINGLET OXYGEN; PHOTOSENSITIZER; NANOPARTICLES; ALBUMIN; CANCER;

D O I：

10.1117/12.2559066

中图分类号：

TH742 [显微镜];

学科分类号：

摘要：

The tetrapyrrole chlorin e6 (Ce6) is actively used in photodynamic therapy (PDT) and as a test drug for sonodynamic therapy due to its ability to generate singlet oxygen. In this work, we have analyzed the absorption, photoluminescence (PL), and PL excitation spectra of Ce6 molecules in a nutrient medium and inside the melanoma cells. An analysis of the results shows that Ce6 inside the cancer cells with a low pH remains in monomeric form. A photodynamic test has also been conducted that confirmed the photodynamic effect produced by Ce6 in cancer cells by changing the signals from Ce6 and cells in the absorption and PL spectra.

引用

页数：6

共 27 条

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