Beta-Blockers and Abdominal Aortic Aneurysm Growth: A Systematic Review and Meta-Analysis

被引：6
作者：
Siordia, Juan A. [1 ]
机构：
[1] Univ Arizona, Banner Univ Med Ctr, Dept Internal Med, 1501 N Campbell Ave, Tucson, AZ 85719 USA
来源：
CURRENT CARDIOLOGY REVIEWS | 2021年 / 17卷 / 04期
关键词：
Beta-Blocker; aortic aneurysm; aorta; medical therapy; blood pressure; meta-analysis; PRACTICE GUIDELINES; MEDICAL-MANAGEMENT; CONTROLLED-TRIAL; EXPANSION RATE; DOUBLE-BLIND; PROPRANOLOL; HYPERTENSION; MODULATION; MORTALITY; BLOCKADE;
D O I：
10.2174/1573403X16999201102213619
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: Aortic aneurysms are worrisome because of their predisposition to dissection and rupture. Beta-blockers are considered first-line therapy for aortic aneurysms. The following meta-analysis assesses if beta-blockers diminish aortic aneurysm growth. Methods: A literature search was performed to collect information on clinical trials that have assessed aortic aneurysm growth between beta-blockers and placebo. The primary endpoint was aortic aneurysm growth rate per year. A forest plot with a random-effects model was used for analysis. Results: Eight clinical trials were included in the analysis. Beta-blockers showed a statistically non-significant effect on aortic aneurysm growth (standard mean difference-0.44; 95% CI [-0.44, 0.00]). Conclusion: Beta-blockers do not significantly influence aortic aneurysm growth. Further studies are required to find a suitable medical therapy to reduce growth rates.
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页数：5
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