Isotretinoin in dermatology

被引：19

作者：

Amichai, B

Grunwald, MH ^{[1
]}

机构：

[1] Ben Gurion Univ Negev, Soroka Med Ctr, Dept Dermatol, IL-84101 Beer Sheva, Israel

[2] Huzot Clin, Dept Dermatol, Ashqelon, Israel

来源：

JOURNAL OF DERMATOLOGICAL TREATMENT | 2000年 / 11卷 / 04期

关键词：

isotretinoin; side effects; therapy;

D O I：

10.1080/095466300750134214

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

BACKGROUND: Isotretinoin (13-cis retinoic acid) revolutionized the treatment of acne, Since the early 1980s patients suffering from severe forms of acne have been treated effectively, with less residual cosmetic or psychological damage. OBJECTIVE: The aim of this article is to provide a wide review of isotretinoin, including its clinical applications in dermatology, side effects and drug interactions. DISCUSSION: Isotretinoin affects epidermal cell growth and differentiation as well as sebaceous gland activity, and exhibits immunomodulatory and antiinflammatory properties, which are important in the treatment of a wide range of other cutaneous diseases - mainly disorders of keratinization and also in proliferative diseases.

引用

页码：219 / 240

页数：22

共 378 条

[91] HEPATIC TOXICITY OF VITAMIN-A AND SYNTHETIC RETINOIDS [J].