A historical overview of chemical research on cannabinoids

被引：169
作者：
Mechoulam, R [1 ]
Hanus, L [1 ]
机构：
[1] Hebrew Univ Jerusalem, Fac Med, Dept Med Chem & Nat Prod, IL-91120 Jerusalem, Israel
来源：
CHEMISTRY AND PHYSICS OF LIPIDS | 2000年 / 108卷 / 1-2期
关键词：
cannabinoids; terpenoids; alkaloids;
D O I：
10.1016/S0009-3084(00)00184-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The chemical research on the plant cannabinoids and their derivatives over two centuries is concisely reviewed. The tortuous path leading to the discovery of the endogenous cannabinoids is described. Future directions, which will probably be followed are delineated. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：1 / 13
页数：13
相关论文
共 77 条
[1]   (R)-METHANANDAMIDE - A CHIRAL NOVEL ANANDAMIDE POSSESSING HIGHER POTENCY AND METABOLIC STABILITY [J].
ABADJI, V ;
LIN, SY ;
TAHA, G ;
GRIFFIN, G ;
STEVENSON, LA ;
PERTWEE, RG ;
MAKRIYANNIS, A .
JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (12) :1889-1893
[2]   AN EFFICIENT NEW CANNABINOID ANTIEMETIC IN PEDIATRIC ONCOLOGY [J].
ABRAHAMOV, A ;
ABRAHAMOV, A ;
MECHOULAM, R .
LIFE SCIENCES, 1995, 56 (23-24) :2097-2102
[3]   NEW ANALOGS OF TETRAHYDROCANNABINOL .19. [J].
ADAMS, R ;
HARFENIST, M ;
LOEWE, S .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1949, 71 (05) :1624-1628
[4]   Structure of cannabinol. III. Synthesis of cannabinol, 1-hydroxy-3-n-amyl-6,6,9-trimethyl-6-dibenzopyran [J].
Adams, R ;
Baker, BR ;
Wearn, RB .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1940, 62 :2204-2207
[5]  
Adams R., 1941, HARVEY LECT, V37, P168
[6]  
AGURELL S, 1986, PHARMACOL REV, V38, P21
[7]  
ARCHER RA, 1986, CANNABINOIDS THERAPE, P86
[8]   Cannabinoid receptor agonists and antagonists [J].
Barth, F .
EXPERT OPINION ON THERAPEUTIC PATENTS, 1998, 8 (03) :301-313
[9]   An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity [J].
Ben-Shabat, S ;
Fride, E ;
Sheskin, T ;
Tamiri, T ;
Rhee, MH ;
Vogel, Z ;
Bisogno, T ;
De Petrocellis, L ;
Di Marzo, V ;
Mechoulam, R .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1998, 353 (01) :23-31
[10]   IDENTIFICATION THROUGH SYNTHESIS OF AN ACTIVE DELTA1(6)-TETRAHYDROCANNABINOL METABOLITE [J].
BENZVI, Z ;
MECHOULA.R ;
BURSTEIN, S .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1970, 92 (11) :3468-&
12345678