Arsenic methylation capacity and obesity are associated with insulin resistance in obese children and adolescents

被引：28
作者：
Lin, Hsiu-Chen [1 ,2 ,3 ]
Huang, Yung-Kai [4 ]
Shiue, Horng-Sheng [5 ,6 ]
Chen, Liang-Sien [1 ,7 ]
Choy, Cheuk-Sing [8 ]
Huang, Shiau-Rung [1 ]
Han, Bor-Cheng [1 ]
Hsueh, Yu-Mei [1 ,9 ]
机构：
[1] Taipei Med Univ, Coll Publ Hlth & Nutr, Sch Publ Hlth, Taipei 110, Taiwan
[2] Taipei Med Univ, Coll Med, Sch Med, Dept Pediat, Taipei 110, Taiwan
[3] Taipei Med Univ Hosp, Dept Lab Med, Taipei, Taiwan
[4] Taipei Med Univ, Coll Oral Med, Sch Oral Hyg, Taipei 110, Taiwan
[5] Chang Gung Mem Hosp, Dept Chinese Med, Taoyuan, Taiwan
[6] Chang Gung Univ, Coll Med, Taoyuan, Taiwan
[7] Keelung Chang Gung Mem Hosp, Dept Family Med, Keelung, Taiwan
[8] Min Sheng Gen Hosp, Dept Emergency, Taoyuan, Taiwan
[9] Taipei Med Univ, Sch Med, Dept Publ Hlth, Coll Med, Taipei 110, Taiwan
来源：
FOOD AND CHEMICAL TOXICOLOGY | 2014年 / 74卷
关键词：
Adolescents; Arsenic methylation capability; HOMA-IR; Insulin resistance; Obesity; DEPENDENT DIABETES-MELLITUS; DRINKING-WATER; UROTHELIAL CARCINOMA; TRIVALENT ARSENICALS; SPECIATION ANALYSIS; SODIUM ARSENITE; EXPOSURE; RISK; METABOLITES; PREVALENCE;
D O I：
10.1016/j.fct.2014.08.018
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
The goal of the present study was to compare the arsenic methylation capacities in elementary school and junior high school students in an area of Taiwan with low arsenic exposure, and explore the influence of both arsenic methylation capacity and obesity on insulin resistance in these children and adolescents using the HOMA-IR index. We recruited 303 elementary school students and 319 junior high school students in Taipei City from September 2007 to November 2011. Concentrations of inorganic arsenic (arsenite + arsenate), monomethylarsonic acid (MMA(v)) and dimethylarsinic acid (DMA(v)) were determined by a high-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry. Insulin resistance was determined by HOMA-IR Elementary school students had significantly lower inorganic arsenic percentage and a higher DMA(v) percentage than junior high school students. It seems that the former had better arsenic methylation capability than the latter. The HOMA-IR value was significantly and positively related to the sum of the urinary inorganic and methylated arsenic (TotalAs) concentrations and also the BMI Z score, with the regression coefficients (beta) being 0.058 (p < 0.001) and 0.001 (p = 0.027), respectively. The higher BMI values and higher TotalAs concentration were associated with higher HOMA-IR values in children and adolescents in Taiwan. (C) 2014 Elsevier Ltd. All rights reserved.
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页码：60 / 67
页数：8
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