Synthesis of ribofuranosyl glycosides of echiguanines A and B, inhibitors of phosphatidylinositol 4-kinase

被引：3
|
作者：
Sanpei, K
Saito, Y
Imoto, M
Umezawa, K
Kato, K
机构：
[1] KEIO UNIV,FAC SCI & TECHNOL,DEPT APPL CHEM,KOHOKU KU,YOKOHAMA,KANAGAWA 223,JAPAN
[2] NIPPON KAYAKU CO LTD,PHARMACEUT GRP,RES LABS,KITA KU,TOKYO 115,JAPAN
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 21期
关键词：
SIGNAL TRANSDUCTION; TRANSFORMED CELLS; CONVENIENT; KINASE;
D O I：
10.1016/0960-894X(96)00459-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis of ribofuranosyl glycosides of echiguanines A and B, PI 4-kinase inhibitors, was achieved from 2-amino-4-chloropyrrolo[2,3-d]pyrimidine and 2,3-O-isopropylidene-5-O-(t-butyl) dimethylsilyl-alpha-D-ribofuranosyl chloride. The ribofuranosyl echiguanine A weakly inhibited PI 4-kinase. Copyright (C) 1996 Elsevier Science Ltd
引用
收藏
页码：2487 / 2490
页数：4
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