Multicomponent one-pot procedure for the synthesis of free α-chiral amines from aldehydes

被引：44
|
作者：
Côté, A [1 ]
Charette, AB [1 ]
机构：
[1] Univ Montreal, Dept Chim, Stn Downtown, Montreal, PQ H3C 3J7, Canada
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 26期
关键词：
D O I：
10.1021/jo0516483
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of free a-chiral amines by a one-pot multicomponent procedure from commercially available starting materials is described. This enantioselective reaction involves a catalytic asymmetric addition of dialkylzinc reagents to N-diphenylphosphinoylimines with use of an air-stable precatalyst complex 1. The a-chiral amines are prepared with a one-pot procedure from alkyl and aryl aldehydes in good yield (41-90%) and with excellent enantioselectivity (90-97% ee).
引用
收藏
页码：10864 / 10867
页数：4
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