Transfer of Cellular and Humoral Anti-Tumor Immunity with Immune T Cells After Stem Cell Transplant (SCT) for Metastatic Breast Cancer Following "Vaccination" with Anti-CD3 x Anti-Her2/Neu Bispecific Antibody (Her2Bi) Armed Activated T Cells

被引:0
|
作者
Thakur, Archana [1 ]
Al-Kadhimi, Zaid [1 ]
Pray, Cassara [2 ]
Tomaszewski, Elyse N. [1 ]
Rathore, Ritesh [3 ]
Steele, Patricia A. [1 ]
Abidi, Muneer H. [1 ]
Ayash, Lois [1 ]
Schalk, Dana L. [1 ]
Myers, Karen [1 ]
Mitchell, Alice [1 ]
Deol, Abhinav [1 ]
Uberti, Joseph P. [1 ]
Ratanatharathorn, Voravit [1 ]
Lum, Lawrence G. [1 ]
机构
[1] Wayne State Univ, Karmanos Canc Inst, Detroit, MI USA
[2] Michigan State Univ, Coll Vet Med, E Lansing, MI 48824 USA
[3] Roger Williams Canc Ctr, Providence, RI USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:835 / 835
页数:1
相关论文
共 50 条
  • [1] Activated T Cells (ATC) Armed with Anti-CD3 X Anti-Her2/Neu Bispecific Antibody (Her2Bi) Is a Potent Immunomodulator.
    Norkina, Oxana
    Thakur, Archana
    Norkin, Maxim
    Paul, Elyse
    Al-Kadhimi, Zaid
    Lum, Lawrence G.
    BLOOD, 2008, 112 (11) : 888 - 888
  • [2] Combining anti-CD3 activated T cells armed with anti-CD3 x anti-Her2 bispecific antibody may provide an additional anti-tumor effect after stem cell transplant for breast cancer.
    Sen, M
    Wankowski, DM
    Lum, LG
    EXPERIMENTAL HEMATOLOGY, 1998, 26 (08) : 743 - 743
  • [3] PRIMED AND BOOSTED ANTI-BREAST CANCER TUMOR IMMUNITY AFTER AUTOLOGOUS PERIPHERAL BLOOD STEM CELL TRANSPLANT (PBSCT): IN VIVO PRIMING WITH T CELLS ARMED WITH ANTI-CD3 X ANTI-HER2/NEU BISPECIFIC ANTIBODY (HER2BI) PRE PBSCT AND BOOSTING AFTER PBSCT WITH ACTIVATED T CELLS (ATC)
    Lum, L. G.
    Thakur, A.
    Al-Kadhimi, Z.
    Abidi, M.
    Ayash, L.
    Cummings, F.
    Rathore, R.
    Uberti, J. P.
    Ratanatharathorn, V
    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2010, 16 (02) : S166 - S166
  • [4] Fate and function of anti-CD3 activated T cells (ATC) armed with OKT3 x anti-Her2/Neu bispecific antibody (Her2Bi) in patients with Her2/neu+ tumors
    Lum, L
    Grabert, R
    Gall, J
    Kouttab, N
    JOURNAL OF IMMUNOTHERAPY, 2003, 26 (06): : S21 - S21
  • [5] Activated T cells armed with anti-CD3 x anti-HER2/neu bispecific antibody I:: Anti-tumor activity and survival in SCID/Beige mice.
    Smith, JA
    Davol, PA
    Kouttab, NM
    Rathore, R
    Elfenbein, GJ
    Lum, LG
    BLOOD, 2002, 100 (11) : 673A - 673A
  • [6] Phase I immunotherapy in women with metastatic breast cancer with activated T cells targeted with anti-CD3 x anti-Her2/neu bispecific antibody
    Lum, L. G.
    Al-Kadhimi, Z.
    Skuba, C.
    Sandborg, R.
    Rathore, R.
    Liu, Q.
    Uberti, J. P.
    Ratanatharathorn, V.
    JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (15)
  • [7] Enhanced anti-breast cancer cyotoxicity, after autologous peripheral blood stem cell transplant (PBSCT) by boosting with multiple infusions of activated T cells (ATC) armed with anti-CD3 x anti-Her2 bispecific antibody (Her2Bi) prior to PBSCT
    Lum, Lawrence G.
    Al-Kadhimi, Zaid
    Skuba, Cassara
    Ratanatharathorn, Voravit
    Uberti, Joseph P.
    BLOOD, 2007, 110 (11) : 807A - 808A
  • [8] Use of anti-CD3 x anti-HER2/neu bispecific antibody for redirecting cytotoxicity of activated T cells toward HER2/neu+ tumors
    Sen, M
    Wankowski, DM
    Garlie, NK
    Siebenlist, RE
    Van Epps, D
    LeFever, AV
    Lum, LG
    JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH, 2001, 10 (02): : 247 - 260
  • [9] Activated T cells armed with anti-CD3 x anti-HER2/neu bispecific antibody III.: Kinetics and survival of armed ATC in prostate cancer patients.
    Rathore, R
    Colvin, GA
    Kouttab, NM
    Falvey, MT
    Grabert, RC
    Smith, JA
    Tiggs, JC
    Cohen, IC
    Maizel, AL
    Quesenberry, PJ
    Elfenbein, GJ
    Lum, LG
    BLOOD, 2002, 100 (11) : 54B - 54B
  • [10] Activated T cells armed with anti-CD3 x anti-HER2/neu bispecific antibody II.: Armed ATC target, kill, divide, and survive.
    Grabert, RC
    Smith, JA
    Kouttab, NM
    Tiggs, JC
    Lum, LG
    BLOOD, 2002, 100 (11) : 55B - 55B