Retinal microvasculature changes in amyloid-negative subcortical vascular cognitive impairment compared to amyloid-positive Alzheimer's disease

被引：32

作者：

Jung, Na-Yeon ^{[1
,2
,3
,4
]}

Han, Jong Chul ^{[5
]}

Ong, Yi Ting ^{[6
]}

Cheung, Carol Yim-lui ^{[7
]}

Chen, Christopher P. ^{[8
]}

Wong, Tien Yin ^{[6
]}

Kim, Hee Jin ^{[3
,4
]}

Kim, Yeo Jin ^{[3
,4
,9
]}

Lee, Juyoun ^{[3
,4
,10
]}

Lee, Jin San ^{[3
,4
,11
]}

Jang, Young Kyoung ^{[3
,4
]}

Kee, Changwon ^{[5
]}

Lee, Kyung Han ^{[12
]}

Kim, Eun-Joo ^{[13
,14
]}

Seo, Sang Won ^{[3
,4
]}

Na, Duk L. ^{[3
,4
]}

机构：

[1] Pusan Natl Univ, Sch Med, Dept Neurol, Yangsan Hosp, Yangsan, South Korea

[2] Res Inst Convergence Biomed Sci & Technol, Yangsan, South Korea

[3] Sungkyunkwan Univ, Dept Neurol, Samsung Med Ctr, Sch Med, 81 Irwon Ro, Seoul 06351, South Korea

[4] Samsung Med Ctr, Neurosci Ctr, Seoul, South Korea

[5] Sungkyunkwan Univ, Dept Ophthalmol, Samsung Med Ctr, Sch Med, Seoul, South Korea

[6] Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore

[7] Chinese Univ Hong Kong, Dept Ophthalmol & Visual Sci, Hong Kong, Peoples R China

[8] Natl Univ Singapore, Dept Pharmacol, Singapore, Singapore

[9] Hallym Univ, Chuncheon Sacred Heart Hosp, Dept Neurol, Coll Med, Chunchon, South Korea

[10] Chungnam Natl Univ Hosp, Dept Neurol, Daejeon, South Korea

[11] Kyung Hee Univ Hosp, Dept Neurol, Seoul, South Korea

[12] Sungkyunkwan Univ, Dept Nucl Med, Samsung Med Ctr, Sch Med, Seoul, South Korea

[13] Pusan Natl Univ, Pusan Natl Univ Hosp, Dept Neurol, Sch Med, Busan, South Korea

[14] Med Res Inst, Busan, South Korea

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2019年 / 396卷

关键词：

Retinal vessels; Alzheimer's disease; Vascular dementia; Amyloid; Cerebral small vessel diseases; CEREBROVASCULAR-DISEASE; VENOUS COLLAGENOSIS; NETWORK ALTERATIONS; DEMENTIA; PATHOLOGY; ABNORMALITIES; DIAGNOSIS; FRACTALS; CRITERIA; VESSELS;

D O I：

10.1016/j.jns.2018.10.025

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and purpose: To investigate small vessel abnormalities in patients with cognitive impairment, we compared retinal microvascular alterations between patients with cognitive impairment related to Alzheimer's disease (ADCI) and those with subcortical vascular cognitive impairment (SVCI). Methods: We prospectively recruited 29 amyloid-positive ADCI patients, 28 amyloid-negative SVCI patients that were confirmed by C-11-PiB-PET scan and 34 individuals with normal cognition (NC). The three groups were compared in terms of retinal vascular variables (retinal fractal dimension, vascular caliber, tortuosity and branching angle) by using a semi-automated, computer-assisted analysis of digital fundus photographs. We also investigated the relationship between retinal variables and white matter hyperintensities (WMH) on MRI. Results: Compared to NC individuals, the SVCI patients had smaller total and arteriolar fractal dimensions, whereas there was no significant difference of fractal dimension between ADCI and NC. Other retinal variables did not differ among the three groups. A significant correlation existed between fractal dimension and WMH volume. Conclusions: Retinal microvascular alterations, especially retinal fractal dimension, may be useful markers that reflect cerebral microvascular changes in patients with SVCI as opposed to ADCI, who had no definite difference in retinal variables compared to the NC group.

引用

页码：94 / 101

页数：8

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[1] Seoul Neuropsychological Screening Battery-Dementia Version (SNSB-D): A Useful Tool for Assessing and Monitoring Cognitive Impairments in Dementia Patients [J].