RADIOTHERAPY FOR LIVER METASTASES: A REVIEW OF EVIDENCE

被引：140

作者：

Hoyer, Morten ^{[1
]}

Swaminath, Anand ^{[2
]}

Bydder, Sean ^{[3
]}

Lock, Michael ^{[4
]}

Romero, Alejandra Mendez ^{[5
]}

Kavanagh, Brian ^{[6
]}

Goodman, Karyn A. ^{[7
]}

Okunieff, Paul ^{[8
]}

Dawson, Laura A. ^{[2
]}

机构：

[1] Aarhus Univ Hosp, Dept Oncol, DK-8000 Aarhus C, Denmark

[2] Univ Toronto, Princess Margaret Hosp, Radiat Med Program, Toronto, ON, Canada

[3] Sir Charles Gairdner Hosp, Perth, WA, Australia

[4] Univ Western Ontario, Dept Oncol, London, ON, Canada

[5] Erasmus MC Daniel den Hoed Canc Ctr, Dept Radiat Oncol, Rotterdam, Netherlands

[6] Univ Colorado Comprehens Canc Ctr, Dept Radiat Oncol, Aurora, CO USA

[7] Mem Sloan Kettering Canc Ctr, Dept Radiat Oncol, New York, NY 10021 USA

[8] Univ Florida, Dept Radiat Oncol, Gainesville, FL USA

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 2012年 / 82卷 / 03期

关键词：

body radiation therapy; Conformal radiotherapy; Brachytherapy; Selective internal radiotherapy; Whole liver radiotherapy; Liver metastases; BODY RADIATION-THERAPY; HEPATIC METASTASES; COLORECTAL-CANCER; PHASE-II; AMERICAN SOCIETY; IRRADIATION; TUMORS; RESECTION; CHEMOTHERAPY; PALLIATION;

D O I：

10.1016/j.ijrobp.2011.07.020

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Over the past decade, there has been an increasing use of radiotherapy (RT) for the treatment of liver metastases. Most often, ablative doses are delivered to focal liver metastases with the goal of local control and ultimately improving survival. In contrast, low-dose whole-liver RT may be used for the palliation of symptomatic diffuse metastases. This review examines the available clinical data for both approaches. The review found that RT is effective both for local ablation of focal liver metastases and for palliation of patients with symptomatic liver metastases. However, there is a lack of a high level of evidence from randomized clinical trials. (C) 2012 Elsevier Inc.

引用

页码：1047 / 1057

页数：11

共 87 条

[1] Hepatic resection for noncolorectal nonendocrine liver Metastases - Analysis of 1452 patients and development of a prognostic model
Adam, Rene
Chiche, Laurence
Aloia, Thomas
Elias, Dominique
Salmon, Remy
Rivoire, Michel
Jaeck, Daniel
Saric, Jean
Le Treut, Yves Patrice
Belghiti, Jacques
Mantion, Georges
Mentha, Gilles
[J]. ANNALS OF SURGERY, 2006, 244 (04) : 524 - 535
[2] Ambrosino G, 2009, ANTICANCER RES, V29, P3381
[3] Daily targeting of intrahepatic tumors for radiotherapy
Balter, JM
Brock, KK
Litzenberg, DW
McShan, DL
Lawrence, TS
Ten Haken, R
McGinn, CJ
Lam, KL
Dawson, LA
[J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2002, 52 (01): : 266 - 271
[4] BARONE RM, 1982, CANCER-AM CANCER SOC, V50, P850, DOI 10.1002/1097-0142(19820901)50:5<850::AID-CNCR2820500508>3.0.CO
[5] 2-2
[6] Phase II trial of high-dose conformal radiation therapy with concurrent hepatic artery floxuridine for unresectable intrahepatic malignancies
Ben-Josef, E
Normalle, D
Ensminger, WD
Walker, S
Tatro, D
Ten Haken, RK
Knol, J
Dawson, LA
Pan, C
Lawrence, TS
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (34) : 8739 - 8747
[7] STEREOTAXIC HIGH-DOSE FRACTION RADIATION-THERAPY OF EXTRACRANIAL TUMORS USING AN ACCELERATOR - CLINICAL-EXPERIENCE OF THE FIRST 31 PATIENTS
BLOMGREN, H
LAX, I
NASLUND, I
SVANSTROM, R
[J]. ACTA ONCOLOGICA, 1995, 34 (06) : 861 - 870
[8] THE PALLIATION OF HEPATIC METASTASES - RESULTS OF THE RADIATION-THERAPY ONCOLOGY GROUP PILOT-STUDY
BORGELT, BB
GELBER, R
BRADY, LW
GRIFFIN, T
HENDRICKSON, FR
[J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1981, 7 (05): : 587 - 591
[9] Bydder S, 2003, Australas Radiol, V47, P284, DOI 10.1046/j.1440-1673.2003.01177.x
[10] TREATMENT WITH COMBINED INTRA-ARTERIAL 5-FUDR INFUSION AND WHOLE-LIVER RADIATION FOR COLON-CARCINOMA METASTATIC TO THE LIVER - PRELIMINARY-RESULTS
BYFIELD, JE
BARONE, RM
FRANKEL, SS
SHARP, TR
[J]. AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 1984, 7 (04): : 319 - 325

← 1 2 3 4 5 6 7 8 9 →