Polybrominated diphenyl ethers in human serum and sperm quality

被引：103

作者：

Akutsu, K. ^{[1
,2
]}

Takatori, S. ^{[1
]}

Nozawa, S. ^{[3
]}

Yoshiike, M. ^{[3
]}

Nakazawa, H. ^{[4
]}

Hayakawa, K. ^{[2
]}

Makino, T. ^{[5
]}

Iwamoto, T. ^{[3
]}

机构：

[1] Osaka Prefectural Inst Publ Hlth, Div Food Chem, Higashinari Ku, Osaka 5370025, Japan

[2] Kanazawa Univ, Grad Sch Nat Sci & Technol, Kanazawa, Ishikawa 9201192, Japan

[3] St Marianna Univ, Sch Med, Dept Urol, Miyamae Ku, Kanagawa 2168511, Japan

[4] Hoshi Univ, Dept Analyt Chem, Shinagawa Ku, Tokyo 1428501, Japan

[5] Tokai Univ, Dept Obstet & Gynecol, Sch Med, Kanagawa 2591143, Japan

来源：

BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY | 2008年 / 80卷 / 04期

关键词：

polybrominated diphenyl ethers; flame retardants; human serum; sperm;

D O I：

10.1007/s00128-008-9370-4

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Polybrominated diphenyl ethers (PBDEs) are widely used flame retardants; currently, they are identified as ubiquitous environmental contaminants. Several studies indicate that PBDEs might affect male fertility. We present the results of a pilot study on the relationship between human serum PBDEs and sperm quality. The PBDE levels in Japan are comparable to those found in European countries. Strong inverse correlations were observed between the serum concentration of 2,2',4,4',5,5'-hexabromodiphenyl ether and sperm concentration (r = -0.841, p = 0.002) and testis size (r = -0.764, p = 0.01). Extensive studies on the relationship between PBDEs and sperm quality are required.

引用

页码：345 / 350

页数：6

共 15 条

[1] Time-trend (1973-2000) of polybrominated diphenyl ethers in Japanese mother's milk
Akutsu, K
Kitagawa, M
Nakazawa, H
Makino, T
Iwazaki, K
Oda, H
Hori, S
[J]. CHEMOSPHERE, 2003, 53 (06) : 645 - 654
[2] [Anonymous], 1999, WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction
[3] Brominated flame retardants: A novel class of developmental neurotoxicants in our environment?
Eriksson, P
Jakobsson, E
Fredriksson, A
[J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 2001, 109 (09) : 903 - 908
[4] IMMUNOLOGICAL AND ENDOCRINE EFFECTS OF THE FLAME-RETARDANT PENTABROMODIPHENYL ETHER (DE-71) IN C57BL/6J MICE
FOWLES, JR
FAIRBROTHER, A
BAECHERSTEPPAN, L
KERKVLIET, NI
[J]. TOXICOLOGY, 1994, 86 (1-2) : 49 - 61
[5] Polybrominated diphenyl ethers in the environment and in people: A meta-analysis of concentrations
Hites, RA
[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2004, 38 (04) : 945 - 956
[6] Exponential increases of the brominated flame retardants, polybrominated diphenyl ethers, in the Canadian arctic from 1981 to 2000
Ikonomou, MG
Rayne, S
Addison, RF
[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2002, 36 (09) : 1886 - 1892
[7] Semen quality of 324 fertile Japanese men
Iwamoto, T
Nozawa, S
Yoshiike, M
Hoshino, T
Baba, K
Matsushita, T
Tanaka, SN
Naka, M
Skakkebæk, NE
Jorgensen, N
[J]. HUMAN REPRODUCTION, 2006, 21 (03) : 760 - 765
[8] Developmental exposure to low-dose PBDE-99: Effects on male fertility and neurobehavior in rat offspring
Kuriyama, SN
Talsness, CE
Grote, K
Chahoud, I
[J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 2005, 113 (02) : 149 - 154
[9] Detailed polybrominated diphenyl ether (PBDE) congener composition of the widely used penta-, octa-, and deca-PBDE technical flame-retardant mixtures
La Guardia, Mark J.
Hale, Robert C.
Harvey, Ellen
[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2006, 40 (20) : 6247 - 6254
[10] In vitro estrogenicity of polybrominated diphenyl ethers, hydroxylated PBDEs, and polybrominated bisphenol A compounds
Meerts, IATM
Letcher, RJ
Hoving, S
Marsh, G
Bergman, Å
Lemmen, JG
van der Burg, B
Brouwer, A
[J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 2001, 109 (04) : 399 - 407

← 1 2 →