Ovarian serous carcinoma: recent concepts on its origin and carcinogenesis

被引：93

作者：

Li, Jie ^{[1
,2
]}

Fadare, Oluwole ^{[3
]}

Xiang, Li ^{[1
,2
]}

Kong, Beihua ^{[1
,2
]}

Zheng, Wenxin ^{[1
,2
,4
,5
]}

机构：

[1] Shandong Univ, Qilu Hosp, Dept Obstet & Gynecol, Jinan 250012, Shandong, Peoples R China

[2] Univ Arizona, Dept Pathol, Coll Med, Tucson, AZ 85724 USA

[3] Vanderbilt Univ, Sch Med, Dept Pathol Microbiol & Immunol, Nashville, TN 37212 USA

[4] Univ Arizona, Dept Obstet & Gynecol, Tucson, AZ USA

[5] Univ Arizona, Arizona Canc Ctr, Tucson, AZ USA

来源：

JOURNAL OF HEMATOLOGY & ONCOLOGY | 2012年 / 5卷

关键词：

Ovarian cancer; Fallopian tube; Carcinogenesis; Serous carcinoma; p53; signatures; PROPHYLACTIC OOPHORECTOMY SPECIMENS; POTENTIAL BORDERLINE TUMORS; FALLOPIAN-TUBE EPITHELIUM; BRCA MUTATION CARRIERS; LOW-GRADE; INTRAEPITHELIAL CARCINOMA; MOLECULAR PATHOGENESIS; SALPINGO-OOPHORECTOMY; PATHOLOGICAL FINDINGS; CANDIDATE PRECURSOR;

D O I：

10.1186/1756-8722-5-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent morphologic and molecular genetic studies have led to a paradigm shift in our conceptualization of the carcinogenesis and histogenesis of pelvic (non-uterine) serous carcinomas. It appears that both low-grade and high-grade pelvic serous carcinomas that have traditionally been classified as ovarian in origin, actually originate, at least in a significant subset, from the distal fallopian tube. Clonal expansions of the tubal secretory cell probably give rise to serous carcinomas, and the degree of ciliated conversion is a function of the degree to which the genetic hits deregulate normal differentiation. In this article, the authors review the evidentiary basis for aforementioned paradigm shift, as well as its potential clinical implications.

引用

页数：11

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