Induction Therapy for Thymoma

被引:9
作者
Ahmad, Usman [1 ]
Huang, James [2 ]
机构
[1] Cleveland Clin, Div Thorac Surg, Dept Cardiothorac Surg, Inst Heart & Vasc, 9500 Euclid Ave,J4-1, Cleveland, OH 44195 USA
[2] Mem Sloan Kettering Canc Ctr, Thorac Serv, Dept Surg, 1275 York Ave, New York, NY 10065 USA
关键词
Thymic tumors; Induction treatment; Neoadjuvant; Chemotherapy; Chemoradiation; SINGLE-INSTITUTION EXPERIENCE; THORACIC SURGEONS DATABASE; LOCALLY ADVANCED THYMOMAS; INVASIVE THYMOMA; PHASE-II; NEOADJUVANT CHEMOTHERAPY; SURGICAL RESECTION; RADIATION-THERAPY; THYMIC TUMORS; STAGE-III;
D O I
10.1016/j.thorsurg.2016.04.011
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Thymomas are uncommon tumors that can present as locally advanced tumors in approximately 30% of the patients. Stage and complete resection are the strongest prognostic factors. For locally advanced tumors, induction treatment may improve the ability to achieve a complete resection. Combination treatment with cisplatin, doxorubicin, and cyclophosphamide is the most commonly used induction regimen. Similar rates of resectability are noted with the use of induction chemotherapy and chemoradiation therapy; however, more tumor necrosis is noted with the addition of radiation.
引用
收藏
页码:325 / +
页数:9
相关论文
共 42 条
[1]   Thymic carcinoma outcomes and prognosis: Results of an international analysis [J].
Ahmad, Usman ;
Yao, Xiaopan ;
Detterbeck, Frank ;
Huang, James ;
Antonicelli, Alberto ;
Filosso, Pier Luigi ;
Ruffini, Enrico ;
Travis, William ;
Jones, David R. ;
Zhan, Yilei ;
Lucchi, Marco ;
Rimner, Andreas .
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2015, 149 (01) :95-+
[2]  
Akaogi E, 1996, J SURG ONCOL, V63, P17
[3]   A phase II trial of erlotinib plus bevacizumab in patients with recurrent thymoma or thymic carcinoma [J].
Bedano, P. M. ;
Perkins, S. ;
Burns, M. ;
Kessler, K. ;
Nelson, R. ;
Schneider, B. P. ;
Risley, L. ;
Dropcho, S. ;
Loehrer, P. J. .
JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (15)
[4]   Induction chemotherapy, cytoreductive surgery and intraoperative hyperthermic pleural irrigation in patients with stage IVA thymoma [J].
Belcher, Elizabeth ;
Hardwick, Timothy ;
Lal, Rohit ;
Marshall, Stuart ;
Spicer, James ;
Lang-Lazdunski, Loic .
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, 2011, 12 (05) :744-746
[5]   FDG PET-CT Aids in the Preoperative Assessment of Patients with Newly Diagnosed Thymic Epithelial Malignancies [J].
Benveniste, Marcelo F. K. ;
Moran, Cesar A. ;
Mawlawi, Osama ;
Fox, Patricia S. ;
Swisher, Stephen G. ;
Munden, Reginald F. ;
Marom, Edith M. .
JOURNAL OF THORACIC ONCOLOGY, 2013, 8 (04) :502-510
[6]   NEOADJUVANT CHEMOTHERAPY WITH ADRIAMYCIN, CISPLATIN, VINCRISTINE AND CYCLOPHOSPHAMIDE (ADOC) IN INVASIVE THYMOMAS - RESULTS IN 6 PATIENTS [J].
BERRUTI, A ;
BORASIO, P ;
RONCARI, A ;
GORZEGNO, G ;
MOSSETTI, C ;
DOGLIOTTI, L .
ANNALS OF ONCOLOGY, 1993, 4 (05) :429-431
[7]   Multimodal management of stages III-IVA malignant thymoma [J].
Bretti, S ;
Berruti, A ;
Loddo, C ;
Sperone, P ;
Casadio, C ;
Tessa, M ;
Ardissone, F ;
Gorzegno, G ;
Sacco, M ;
Manzin, E ;
Borasio, P ;
Sannazzari, GL ;
Maggi, G ;
Dogliotti, L .
LUNG CANCER, 2004, 44 (01) :69-77
[8]   Thymic epithelial turnours: A population-based study of the incidence, diagnostic procedures and therapy [J].
de Jong, Wouter K. ;
Blaauwgeers, Johannes L. G. ;
Schaapveld, Michael ;
Timens, Wim ;
Klinkenberg, Theo J. ;
Groen, Harry J. M. .
EUROPEAN JOURNAL OF CANCER, 2008, 44 (01) :123-130
[9]   Thymic tumors [J].
Detterbeck, FC ;
Parsons, AM .
ANNALS OF THORACIC SURGERY, 2004, 77 (05) :1860-1869
[10]   Management of Stage I and II Thymoma [J].
Detterbeck, Frank C. ;
Parsons, Alden M. .
THORACIC SURGERY CLINICS, 2011, 21 (01) :59-+